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1- Shiraz University
Abstract:  
Purpose of the study: The ginseng extract is an herb that has been used for many purposes such as analgesic effect. Dopamine D2 receptors are involved in the regulation of pain in humans. Therefore, the aim of present investigation was to study how pretreatment with aqueous alcoholic extract of ginseng can affects dopamine D2 receptors pain sensitivity.
Methods: Forty-five adult male rat weighing 250±20 were used. Animal were maintained in standard condition temperature 21-24°C. Experimental groups were as follow: 1- Sham1 (intraperitoneal (IP) injection of normal saline); 2- Sham2 (intracerebroventicular (ICV) injection of artificial cerebrospinal fluid (ACSF)); 3- experimental 1(IP injection of ginseng extract) 4 and 5 experimental 2 and 3 (IP injection ginseng extract + bromocriptine 10 and 30 ug/rat by ICV injection) 6 and 7 experimental 4 and 5 (IP injection of ginseng extract + chloropromazine 20 and 40 ug/rat by ICV injection). Ginseng extract 100 mg/kg/day were used for 7 days. Pain sensitivity test were done in all group by formalin test. Lateral ventricle was cannulated unilaterally by stereotaxic procedure.
Results: Our data showed that ginseng 100 mg/kg/day significantly (p<0.05) decreased pain sensitivity compared to sham1. Bromocriptine in two doses significantly decreased pain sensitivity compared to sham 2. Chlorpromazine in high doses significantly increased pain sensitivity compared to sham2.
Conclusion: The present results indicate that ginseng can modulate the D2 receptor of dopamine system in control of pain sensitivity in formalin test; because bromocriptine and ginseng had similar effect it seems that they had synergistic effect.
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2018/07/11 | Accepted: 2018/12/19

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