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1- Azad University-Science & Reseach Branch,Tehran,Iran
2- Tarbiat Modaress University,Tehran,Iran
3- Azad University- Science & Research Branch,Tehran,Iran
4- Shahid Beheshti University,Tehran,Iran
Background: Schizophrenia[1] is a chronic heterogenic mental disorder. It is also a polygenic disorder formed by various molecular pathways. Many genes interfere in development of SCZ. All four genes, NrCAM, PRODH, ANK3, and ANKK1 were previously reported to be association with Schizophrenia. The NrCAM contributes to creating cognitive deficiencies through the CAM’s signaling pathway(Zhang, Yu et al. 2015). PRODH plays important role in creating SCZ negative symptoms through the signaling pathway of glutamatergic and through the NMDA receptor. ANK3 affects ion channel and molecular adhesion in ranvier and initial segments of axons, leading to mental retardation, sleep disorder and SCZ. ANKK1 encodes a protein kinase and was reported to be associated with alcohol addiction, Attention Deficit Hyperactivity Disorder (ADHD) and SCZ.
Objective: This study aimed to investigating the association between candidate SNPs and variants of four genes, NrCAM, PRODH, ANK3, and ANKK1 and SCZ in an Iranian sample of patients with schizophrenia.
Method: The subjects were selected from Schizophrenic patients referring to Psychiatric Ward of Imam-Hussein Hospital and Schizophrenic Patients Support Institution (AHEBBA). 95 (30 Schizo Affective patients, 57 Paranoid patients and 8 disorganized) patients were recruited as the subjects in present case-control association study. 120 healthy subjects were recruited from the staff of the Tehran Medical Genetics Laboratory and a group of students from Science and Research Branch of Islamic Azad University in Tehran. The genotypes were determined with molecular genotyping techniques of PCR-RFLP, ARMs-PCR and Cycle sequencing. Results were analyzed by Chi-Square test to investigate significant differences between cases and controls.
Results: The incidence of schizophrenia was 68% and 32% among men and women, respectively. The evaluation of allelic association between schizophrenia and all candidate SNPs, showed a significant association between, NrCANchr('39')s SNP rs10235968 and SCZ (P=0.001). Incidence of the allele-C among schizophrenic patients and healthy group was 66.3% and 50%, respectively, while the incidence of allele-T among the patients and healthy groups was 33.7% and 50%, respectively. No association was found between other candidate SNPs and SCZ among the subjects.
[1] SCZ
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2018/05/28 | Accepted: 2019/04/6 | Published: 2018/03/15

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