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1- Department of Biomedical Engineering, Islamic Azad University-Tehran North Branch, Tehran, Iran
Abstract:  
Introduction: Hydrocephalus is the most prevailing diseases in children, leading to brain surgery. However, pathophysiology of the disease is highly complicated and still unknown.
Methods: Endoscopic third ventriculostomy (ETV) and ventriculoperitoneal (VPS) are among the common treatment methods of hydrocephalus. Compare of cerebrospinal fluid (CSF) hydrodynamic parameters and efficiency of the treatment methods carried out with numerical simulation and clinical follow-up of patients.
Results: Studies have shown that in patients under 19 years of age suffering from hydrocephalus related to a posterior fossa brain tumor (PFBT), cumulative failure rate have been 21% and 29% in ETV and VPS shunt surgery, respectively .At first, ETV survival curve showed sharp decrease and after two months it became fixed; in turn, VPS curve made a gradual decrease and reached to a level lower than ETV curve after 5.7 months. Post-surgery complications in ETV and VPS methods have been 17% and 31%, respectively. In infants younger than 12 months with hydrocephalus related to congenital aqueduct stenosis (AS), and also elderly patients suffering from normal pressure hydrocephalus (NPH), ETV has been a better treatment option. Computer simulations showed that the maximum CSF pressure is the most suitable hydrodynamic index to evaluate the efficacy of treatment in these patients. After treatment by the ETV and shunt methods, CSF pressure decreased about 9 and 5.3 times, respectively and 2.5 years after shunt implantation, this number returned to normal limits of healthy subjects.
Type of Study: Review | Subject: Computational Neuroscience
Received: 2018/05/17 | Accepted: 2018/08/26

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