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1- Iran University of Medical Sciences
2- Tehran University of Medical Sciences
Abstract:  

Introduction: Impaired sense of smell has a remarkable impact on quality of life. It is seen in a variety of neurodegenerative diseases such as Parkinson’s disease. In this study we assessed the olfactory function in patients with multiple sclerosis (MS) by sniff magnitude test (SMT).

Material and methods: A cross-sectional study was conducted on 48 patients with MS. A questionnaire including demographic and clinical variables was completed for each patient. The SMT was used for evaluation of olfactory function.

Results: Olfactory dysfunction was found in 14.6% of patients (8.3% hyposmia and 6.3% anosmia). Older age, longer disease duration, higher hospital admission rate, lower mini-mental status examination (MMSE) score and secondary progressive course of MS were significantly related to olfactory dysfunction.

Conclusion: Secondary progressive MS and markers of advanced disease toward neurodegenerative phase (including older age, longer disease duration and lower cognitive function) can be associated with olfactory dysfunction in MS patients.

 

Type of Study: Original | Subject: Clinical Neuroscience
Received: 2018/04/29 | Accepted: 2020/02/12 | Published: 2018/03/15

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