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1- Colorectal Research Center, Iran University of Medical Sciences,Tehran, Iran.
2- Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
3- Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
4- Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. 4. Department of Parasitology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
5- Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Introduction: The present systematic review and meta-analysis plans to achieve and present a general conclusion regarding the role of posterior tibial nerve stimulation (PTNS) in control of fecal incontinence (FI).
Methods: Two independent reviewers carried out an extensive search in electronic databases of Medline, Embase, Scopus, Web of Science, CENTRAL, and CINAHL until the end of 2016. Only randomised clinical trial were included. The studied outcomes included FI episodes, FI score, resting pressure, squeezing pressure, and maximum tolerable pressure. Data were reported as standardized mean differences (SMD) with 95% confidence interval (95% CI).
Results: Finally, 5 articles were included in the present study (249 patients under treatment with PTNS and 239 in the sham group). Analyses showed that PTNS leads to a significant decrease in number of FI episodes (SMD=-0.38; 95% CI: -0.67-0.10; p=0.009). Yet, it did not have an effect on FI score (SMD=0.13; 95% CI: -0.49-0.75; p=0.68), resting pressure (SMD=0.12; 95% CI: -0.14-0.37; p=0.67), squeezing pressure (SMD=-0.27; 95% CI: -1.03-0.50; p=0.50), and maximum tolerable pressure (SMD=-0.10; 95% CI: -0.40-0.24; p=0.52).
Conclusion: Based on the results, it seems that prescription of PTNS alone cannot lead to a significant improvement in FI.
Type of Study: Review | Subject: Behavioral Neuroscience
Received: 2018/04/29 | Accepted: 2018/07/28

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