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1- Department of Neurosciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Research Center for Psychiatry and Behavior Science, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:  
Purpose: Global cerebral ischemia (GCI) causes neuronal damage that leads to neurological and cognitive complications. Curcumin has anti-inflammatory, antioxidant and neuroprotective properties, which makes it a potential candidate for improving GCI complications. The aim of this study was to investigate the effects of curcumin on neurological and memory deficits as well as spatial neuronal distribution in the CA1 region following GCI in rats.
Methods: 56 Sprague-Dawley male rats were randomly assigned into four groups of sham, control, curcumin 50, and 100­mg/kg (n=14/group). Each group was divided into two subgroups i.e. short- (7­days) and long-term (28­days) treatment period. Neurological severity score (NSS), passive-avoidance task and traction test was performed at postoperative days 0, 1, 2, 3, 7, 14, 21, and 28.  Novel object recognition test and Voronoi tessellation were carried out on days 7 and 28 after global ischemia.
Results: Curcumin­ 100­mg/kg significantly decreased NSS on postoperative days 7 and 28 in comparison with the control (p<0.001) and curcumin 50­mg/kg groups (p<0.05-p<0.001); increased step-through latency times on postoperative days 3-28 and 14-28 in comparison to the control (p<0.05-p<0.001) and curcumin 50mg/kg groups (p<0.01-p<0.001), respectively. It also increased preference index in novel object test in the 28-day treatment group following GCI. Curcumin­ 100­mg/kg was able to keep neuronal aggregation in the CA1 region after GCI close to what is generally observed in normal rats.
Conclusions: This study showed that curcumin could improve memory and neurological deficits and restored CA1 irregular neuronal distribution following GCI in a time-dependent manner with the higher dose being more effective than the lower dose of curcumin. Curcumin might have beneficial effects in reducing brain complications after ischemia.
 
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2018/03/12 | Accepted: 2018/10/3

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