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1- Shiraz University of Medical Sciences, Shiraz, Iran
There are some evidences indicating that the rate of AD is lower in curry consuming populations. Then, there has been an effort to elucidate if curcumin -as the main ingredient of turmeric- might affect the process of AD. Howbeit, in clinical trials of AD, a 6 month curcumin treatment failed to show any progress which might be attributable to its low bioavailability. In this line, a recent human study revealed that a more bioavailable solid lipid curcumin enhances cognition in aged adults. Using BSA (bovine serum albumin), this study aimed to convert curcumin to nano size and assess its protective effect against scopolamine induced passive avoidance memory retrieval deficit. Nanocurcumin was prepared via dissolvation method. Male NMRI mice (20–25 g body weight) were used. The effective doses of nanocurcumin were chosen according to the initial pilot test. The mice were treated with nanocurcumin 15 or 20 mg/kg/p.o or distilled water for 10 days.  On day 10, the animals were habituated and trained in passive avoidance apparatus. The retention trial was performed 24 hours later. Scopolamine (1 mg/kg/i.p.) or saline was administered 30 min before retention test. The findings indicated that nanocurcumin in doses 15 or 20 mg/kg/p.o prevented the retrieval deficit induced by scopolamine while natural curcumin in its equivalent doses did not have such an effect. Furthermore, nanocurcumin by itself improved memory retention comparing to control group. These findings imply that the potential anti-amnesic effects of curcumin might be observed by producing and using its nanoformulation form.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2018/03/4 | Accepted: 2018/10/13 | Published: 2018/11/28

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