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1- Semnan University
2- Arak University of Medical Sciences
Abstract:  
Introduction: This study aimed to compare the effectiveness of computer-based, manual-based, and combined cognitive rehabilitation to improve cognitive functions among patients with relapsing-remitting multiple sclerosis.
Methods: In the quasi-experimental design with the , posttest, and 2-month follow up, sixty female patients with relapsing-remitting multiple sclerosis were selected by convenience sampling and randomly assigned to three experimental groups (computer-based, manual-based, and combined cognitive rehabilitation, each group including 12 patients), a sham (12 patients) and a control group (12 patients). The interventions were conducted in 21 sessions for experimental groups during 5 months. The sham group as physical rehabilitation intervention and the control group received no intervention. Participants were assessed by Psychiatric-Neurological Profile, Mini-Mental State Examination Inventory, Kurtzke Expanded Disability Status Scale, Stroop Color and Word Test, Wisconsin Card Sorting Test, and Paced Auditory Serial Addition Test. Data were analyzed by repeated measures multivariate analysis of variance with SPSS-22 software.
Results: The effect of group factor is not significant (η2=0.129), but the effect of time (η2=0.884) and interaction effect of time and group (η2=0.295) are significant (P<0.05). There is no significant difference between the effects of all three rehabilitation interventions (P>0.05). In posttest totally and in follow up partially, all comparisons among three experimental groups with control and sham groups were statistically significant (P<0.05).
Conclusion: Cognitive rehabilitation is effective to improve cognitive functions in patients with relapsing-remitting multiple sclerosis. So, these interventions are recommended for application along with other treatment protocols to treat relapsing-remitting multiple sclerosis in clinical settings.
Type of Study: Original | Subject: Cognitive Neuroscience
Received: 2017/09/14 | Accepted: 2019/03/19

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