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1- Zanjan University of Medical Sciences
2- Shahid Beheshti University
3- MD.PhD. Zanjan University of Medical Sciences
Introduction: Brain ischemic reperfusion injury (IRI) caused activation of different pathophysiological processes and changes of physiological conditions such as blood sugar (BS). An increase in BS after stroke is associated with poor clinical outcomes. Erythropoietin has been shown to be effective on both inflammation and BS reduction. Therefore, in this study the erythropoietin pre-treatment effect on BS and its relationship to inflammatory markers after brain IRI was targeted.
MethodS: Thirty adult male Wistar rats randomly divided into 5 groups: sham, control and 3 pretreatment groups: single-dose, double-dose and triple-time dose that received 1000 U/Kg of Erythropoietin before stroke induction in different times intraperitoneally. A rat model of IRI was established by middle cerebral artery occlusion (MCAO) for 60 minutes. Infarct volume, neurological defects, IL-1α and IL-6 serum levels were evaluated 24 hours after reperfusion. Also BS was measured in 1, 6 & 24 hours later .
Results: single-dose of erythropoietin significantly decreased infarct volume and improved neurological defects which was associated with a decreased serum level of  IL-1α and IL-6 but higher doses of erythropoietin administration had adverse effects on histological, neurological and inflammatory results. Also, erythropoietin significantly increased BS in a dose-depended manner.  
Discussion: Erythropoietin could reduce brain IRI by reducing inflammation and BS stabilization . The results of the present study demonstrated a relationship between inflammatory factors and hyperglycemia after IRI and showed that erythropoietin may be useful for preventing brain IRI, but its higher doses should be used with caution due to possible side effects.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2017/08/31 | Accepted: 2018/04/30 | Published: 2018/05/13

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