Volume 1, Issue 1 (Autumn 2009 -- 2009)                   BCN 2009, 1(1): 3-6 | Back to browse issues page

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Mehdizadeh M, Taghi Joghataei M, Nobakht M, Aryanpour R. Neuroprotective effect of quercetin in a model of Parkinson’s disease in rat: A histochemical analysis. BCN 2009; 1 (1) :3-6
URL: http://bcn.iums.ac.ir/article-1-6-en.html

Parkinson's disease (PD) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. Quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. Therefore, its neuroprotective effect in a model of Parkinson’s disease in rat was evaluated.
Methods: For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with quercetin (20 mg/kg i.p.) 1 hour before surgery and treated once a day for one month. Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted.
Results: Number of Nissl-stained neurons in left side of SNC of lesion group was lower relative to sham-operated group (p<0.005) and it was higher in quercetin-treated lesion group as compared to untreated lesion group (p<0.01).
Discussion: Flavonoid quercetin administration for one month could protect the neurons of SNC against 6-OHDA toxicity. 

Type of Study: Original |
Received: 2009/07/27 | Published: 2009/01/15

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