en
jalali
1395
10
1
gregorian
2017
1
1
8
1
online
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fulltext
en
Protective Effects of Proline–Rich Peptide in a Rat Model of Alzheimer Disease: An Electrophysiological Study
Introduction: Alzheimer disease (AD) is the most common form of dementia in the elderly that slowly destroys memory and cognitive functions. The disease has no cure and leads to significant structural and functional brain abnormalities. To facilitate the treatment of this disease, we aimed to investigate proline-rich peptide (PRP-1) action of hypothalamus on hippocampal (HP) neurons and dynamics of their recovery, after intracerebroventricular (ICV) injection of amyloid-β (Aβ).
Methods: Experiments were carried out on 24 adult, male Albino rats (average weight: 230±30 g). The animals were randomly divided into 3 groups (control, Aβ, and Aβ plus PRP-1). Electrophysiological patterns of hippocampal neurons in response to stimulation of entorhinal cortex (EC) with high frequency stimulation (50 Hz) were studied.
Results: It was found that Aβ (25-35) suppresses the electrical activity of hippocampal neurons. The PRP-1 would return this activity to normal levels.
Conclusion: In general, PRP-1 has protective effect against AD-related alterations induced byamyloid peptides. This protective effect is probably due to stimulation of the immune and glia system.
Hypothalamic Proline–Rich Peptide (PRP-1), Alzheimer disease, Amyloid-β, Hippocampus
5
12
http://bcn.iums.ac.ir/browse.php?a_code=A-10-816-1&slc_lang=en&sid=1
2016/05/13
1395/2/24
2016/09/10
1395/6/20
Naser
Khalaji
Department of Physiology, School of Medicine, Uremia University of Medical Sciences, Uremia, Iran.
khalaji.naser@gmail.com
0031947532846009992
0031947532846009992
Yes
John
Sarkissian
Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia, Yerevan, Republic of Armenia.
jsarkissyan@neuroscience.am
0031947532846009993
0031947532846009993
No
Vergine
Chavushyan
Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia, Yerevan, Republic of Armenia.
verginechavushyan@gmail.com
0031947532846009994
0031947532846009994
No
Vaghinak
Sarkisian
Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia, Yerevan, Republic of Armenia.
vsargsyan@neuroscience.am
0031947532846009995
0031947532846009995
No
en
Diffusion Tensor Imaging for Glioma Grading: Analysis of Fiber Density Index
Introduction: The most common primary tumors of brain are gliomas and tumor grading is essential for designing proper treatment strategies. The gold standard choice to determine grade of glial tumor is biopsy which is an invasive method. The purpose of this study was to investigatethe role of fiber density index (FDi) by means of diffusion tensor imaging (DTI) (as a noninvasive method) in glial tumor grading.
Methods: A group of 20 patients with histologically confirmed diagnosis of gliomas wereevaluated in this study. We used a 1.5 Tesla MR system (AVANTO; Siemens, Germany) with a standard head coil for scanning. Multidirectional diffusion weighted imaging (measured in 12 noncollinear directions), and T1 weighted nonenhanced were performed for all patients. We defined two regions of interest (ROIs); 1) White matter fibers near the tumor and 2) Similar fibers in the contralateral hemisphere.
Results: FDi of the low-grade gliomas was higher than those of high-grade gliomas, which was significant (P=0.017). FDi ratio (ratio of fiber density in vicinity of the tumor to homologous fiber tracts in the contralateral hemisphere) is higher in low-grade than high-grade tumors, (P=0.05). In addition, we performed ROC (receiver operating characteristic) curve and the area under
curve (AUC) was 0.813(P=0.013).
Conclusion: Our findings prove significant difference in FDi near by low-grade and high-grade gliomas. Therefore, FDi values and ratios are helpful in glial tumor grading.
Diffusion tensor imaging, Neoplasm grading, Glioma, Fiber density index
13
18
http://bcn.iums.ac.ir/browse.php?a_code=A-10-863-1&slc_lang=en&sid=1
2016/05/132016/04/19
1395/1/31
2016/09/102016/07/5
1395/4/15
Fariba
Davanian
Department of Radiology Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
f.davanian@gmail.com
0031947532846009996
0031947532846009996
No
Fariborz
Faeghi
Department of Radiology Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
f_faeghi@sbmu.ac.ir
0031947532846009997
0031947532846009997
Yes
Sohrab
Shahzadi
Department of Neurosurgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
0031947532846009998
0031947532846009998
No
Zahra
Farshifar
Department of Radiology Technology, School of Paramedical, Shiraz University of Medical Sciences, Shiraz, Iran.
0031947532846009999
0031947532846009999
No
en
Neural Imaging Using Single-Photon Avalanche Diodes
Introduction: This paper analyses the ability of single-photon avalanche diodes (SPADs) for neural imaging. The current trend in the production of SPADs moves toward the minimumdark count rate (DCR) and maximum photon detection probability (PDP). Moreover, the jitter response which is the main measurement characteristic for the timing uncertainty is progressing.
Methods: The neural imaging process using SPADs can be performed by means of florescence lifetime imaging (FLIM), time correlated single-photon counting (TCSPC), positron emission tomography (PET), and single-photon emission computed tomography (SPECT).
Results: This trend will result in more precise neural imaging cameras. While achieving low DCR SPADs is difficult in deep submicron technologies because of using higher doping profiles, higher PDPs are reported in green and blue part of light. Furthermore, the number of pixels integrated in the same chip is increasing with the technology progress which can result in the higher resolution of imaging.
Conclusion: This study proposes implemented SPADs in Deep-submicron technologies to be used in neural imaging cameras, due to the small size pixels and higher timing accuracies.
Neuroimaging, Medical imaging
19
26
http://bcn.iums.ac.ir/browse.php?a_code=A-10-831-1&slc_lang=en&sid=1
2016/05/132016/04/192016/05/6
1395/2/17
2016/09/102016/07/52016/09/1
1395/6/11
Mohammad Azim
Karami
Department of Electronic Engineering, School of Electrical Engineering, University of Science and Technology, Tehran, Iran.
karami@iust.ac.ir
00319475328460010000
00319475328460010000
Yes
Misagh
Ansarian
Department of Electronic Engineering, School of Electrical Engineering, University of Science and Technology, Tehran, Iran.
azimkarami@gmail.com
00319475328460010001
00319475328460010001
No
en
Event-Related Potentials of Bottom-Up and Top-Down Processing of Emotional Faces
Introduction: Emotional stimulus is processed automatically in a bottom-up way or can be processed voluntarily in a top-down way. Imaging studies have indicated that bottom-up and top-down processing are mediated through different neural systems. However, temporal differentiation of top-down versus bottom-up processing of facial emotional expressions has remained to be clarified. The present study aimed to explore the time course of these processes as indexed by the emotion-specific P100 and late positive potential (LPP) event-related potential (ERP) components in a group of healthy women.
Methods: Fourteen female students of Alzahra University, Tehran, Iran aged 18–30 years, voluntarily participated in the study. The subjects completed 2 overt and covert emotional tasks during ERP acquisition.
Results: The results indicated that fearful expressions significantly produced greater P100 amplitude compared to other expressions. Moreover, the P100 findings showed an interaction between emotion and processing conditions. Further analysis indicated that within the overt condition, fearful expressions elicited more P100 amplitude compared to other emotional expressions. Also, overt conditions created significantly more LPP latencies and amplitudes compared to covert conditions.
Conclusion: Based on the results, early perceptual processing of fearful face expressions is enhanced in top-down way compared to bottom-up way. It also suggests that P100 may reflect an attentional bias toward fearful emotions. However, no such differentiation was observed within later processing stages of face expressions, as indexed by the ERP LPP component, in a topdown versus bottom-up way. Overall, this study provides a basis for further exploring of bottomup and top-down processes underlying emotion and may be typically helpful for investigating the temporal characteristics associated with impaired emotional processing in psychiatric disorders.
Top-down processing, Bottom-up processing, Emotional faces, Eventrelated potential, P100, Late positive potential
27
36
http://bcn.iums.ac.ir/browse.php?a_code=A-10-871-1&slc_lang=en&sid=1
2016/05/132016/04/192016/05/62016/01/17
1394/10/27
2016/09/102016/07/52016/09/12016/05/27
1395/3/7
Afsane
Moradi
Department of Psychology, School of Education of Psychology, University of Alzahra, Tehran, Iran.
moradi.afsane@gmail.com
00319475328460010002
00319475328460010002
Yes
Seyed Abolghasem
Mehrinejad
Department of Psychology, School of Education of Psychology, University of Alzahra, Tehran, Iran.
ab_mehrinejad@yahoo.com
00319475328460010003
00319475328460010003
No
Mohammad
Ghadiri
Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
ghadiri_mohamad@yahoo.com
00319475328460010004
00319475328460010004
No
Farzin
Rezaei
Department of Psychiatry, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
frrezaie@yahoo.com
00319475328460010005
00319475328460010005
No
en
Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats
Introduction: Glabrous skin and hairy skin are innervated by different types of noxious fibers. However, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin.
Methods: In this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into either glabrous skin (plantar surface) of the hind paw or hairy skin of the hin limb in adult rats.
Results: A typical biphasic nociceptive response was seen after formalin injection into the plantar surface of the hind paw. A brief interphase separates the first and second phases where nociceptive behaviors were barely spotted. However, following subcutaneous injection into the hairy skin nociceptive behaviors were only seen after 10 minutes of formalin injection, which correlates in time with the second phase of the formalin response. First phase nociceptive behaviors were
never seen with hairy skin injection, even following multiple injections of formalin.
Conclusion: These data suggest that nociceptive behaviors and spinal responses induced by formalin injections to glabrous and hairy skin areas are different, and that the first and second phases may be mediated through different noxious afferent fibers.
Formalin test, Hairy skin, Glabrous skin, Tonic pain, Nociception
37
42
http://bcn.iums.ac.ir/browse.php?a_code=A-10-257-9&slc_lang=en&sid=1
2016/05/132016/04/192016/05/62016/01/172016/06/17
1395/3/28
2016/09/102016/07/52016/09/12016/05/272016/11/29
1395/9/9
Elaheh
Erami
Department of Nursing, Faculty of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
00319475328460010006
00319475328460010006
No
Hassan
Azhdari-Zarmehri
Department of Medical Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
azhdarih1@thums.ac.ir
00319475328460010007
00319475328460010007
Yes
Keiji
Imoto
Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
00319475328460010008
00319475328460010008
No
Hidemasa
Furue
School of Life Science, University for Advanced studies (SOKENDAI), Okazaki, Japan.
00319475328460010009
00319475328460010009
No
en
Reliability of Motor Evoked Potentials Induced by Transcranial Magnetic Stimulation: The Effects of Initial Motor Evoked Potentials Removal
Introduction: Transcranial magnetic stimulation (TMS) is a useful tool for assessment of corticospinal excitability (CSE) changes in both healthy individuals and patients with brain disorders. The usefulness of TMS-elicited motor evoked potentials (MEPs) for the assessment of CSE in a clinical context depends on their intra-and inter-session reliability. This study aimed to evaluate if removal of initial MEPs elicited by using two types of TMS techniques influences the reliability scores and whether this effect is different in blocks with variable number of MEPs.
Methods: Twenty-three healthy participants were recruited in this study. The stimulus intensity was set at 120% of resting motor threshold (RMT) for one group while the stimulus intensity was adjusted to record MEPs up to 1 mV for the other group. Twenty MEPs were recorded at 3 time points on 2 separate days. An intra-class correlation coefficient (ICC) reliability with absolute agreement and analysis of variance model were used to assess reliability of the MEP amplitudes for blocks with variable number of MEPs.
Results: A decrease in ICC values was observed with removal of 3 or 5 MEPs in both techniques when compared to all MEP responses in any given block. Therefore, removal of the first 3 or 5 MEPs failed to further increase the reliability of MEP responses.
Conclusion: Our findings revealed that a greater number of trials involving averaged MEPs can influence TMS reliability more than removal of the first trials.
Transcranial magnetic stimulation, Reliability, Evoked response variability, First dorsal interosseous muscles
43
50
http://bcn.iums.ac.ir/browse.php?a_code=A-10-847-1&slc_lang=en&sid=1
2016/05/132016/04/192016/05/62016/01/172016/06/172016/01/2
1394/10/12
2016/09/102016/07/52016/09/12016/05/272016/11/292016/04/16
1395/1/28
Fahimeh
Hashemirad
Department of Physiotherapy, School of Primary Health Care, Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
fahimeh.hashemirad@monash.edu
00319475328460010010
00319475328460010010
Yes
Maryam
Zoghi
Department of Medicine at Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.
00319475328460010011
00319475328460010011
No
Paul B
Fitzgerald
Monash Alfred Psychiatry Research Centre, Alfred and Monash University Central Clinical School, Melbourne, Australia.
00319475328460010012
00319475328460010012
No
Shapour
Jaberzadeh
Department of Physiotherapy, School of Primary Health Care, Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
00319475328460010013
00319475328460010013
No
en
Analgesic Effect of 17β-Estradiol on Nucleus Paragigantocellularis Lateralis of Male Rats Mediated Via GABAA Receptors
Introduction: Beside its autonomic functions, the nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. 17β-Estradiol is a neuroactive steroid found in several brain areas such as LPGi. Intra-LPGi microinjection of 17β-estradiol can elicit the analgesic responses. 17β-Estradiol modulates nociception by binding to estrogenic receptors as well as allosteric interaction with other membrane-bound receptors like GABAA receptors. This study aimed to examine the role of GABAA receptors in the pain modulating effect of intra-LPGi injection of 17β-estradiol.
Methods: To study the antinociceptive effects of 17β-estradiol, cannulation into the LPGi nucleus of male Wistar rats was performed. About 500 nL of drug was administered 15 minutes prior to formalin injection (50 μL of 4%). Then, formalin-induced flexing and licking behaviors were recorded for 60 minutes. For evaluating the role of GABAA receptors in the estradiol-induced pain modulation, 17β-estradiol was administered into the LPGi nucleus 15 minutes after the injection of 25 ng/μL bicuculline (the GABAA receptor antagonist). Then, the formalin-induced responses were recorded.
Results: The results of the current study showed that intra-LPGi injection of 17β-estradiol decreased the flexing duration in both phases of formalin test (P<0.001); but it only attenuated the second phase of licking behavior (P<0.001). 17β-estradiol attenuated the second phase of formalin test of both behaviors (P<0.001). Bicuculline prevented the antinociceptive effect
of intra-LPGi 17β-estradiol in both first and second phases of formalin-induced responses (P<0.001).
Conclusion: According to the results of this study, the analgesic effect of intra-LPGi 17β-estradiol on the formalin-induced inflammatory pain might be mediated via GABAA receptors.
17β-Estradiol, GABAA receptor, Pain, Analgesia
51
60
http://bcn.iums.ac.ir/browse.php?a_code=A-10-797-1&slc_lang=en&sid=1
2016/05/132016/04/192016/05/62016/01/172016/06/172016/01/22016/02/26
1394/12/7
2016/09/102016/07/52016/09/12016/05/272016/11/292016/04/162016/08/22
1395/6/1
Roghaieh
Khakpay
Department of Animal Science, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
rkhakpai@gmail.com
00319475328460010014
00319475328460010014
Yes
Maryam
Azaddar
Department of Animal Science, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
maryam.azaddar@yahoo.com
00319475328460010015
00319475328460010015
No
Fatemeh
Khakpay
Department of Biology, Faculty of Basics Sciences, Varamin Branch, Islamic Azad University, Pishva, Iran.
khakpai@gmail.com
00319475328460010016
00319475328460010016
No
Homeira
Hatami Nemati
Department of Animal Science, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
homeirahatami@yahoo.com
00319475328460010017
00319475328460010017
No
en
Power Spectral Density Analysis of Purkinje Cell Tonic and Burst Firing Patterns From a Rat Model of Ataxia and Riluzole Treated
Introduction: Purkinje Cell (PC) output displays a complex firing pattern consisting of high frequency sodium spikes and low frequency calcium spikes, and disruption in this firing behavior may contribute to cerebellar ataxia. Riluzole, neuroprotective agent, has been demonstrated to have neuroprotective effects in cerebellar ataxia. Here, the spectral analysis of PCs firing in control, 3-acetylpyridine (3-AP), neurotoxin agent, treated alone and riluzole plus 3-AP treated were investigated to determine changes in the firing properties. Difference in the power spectra of tonic and burst firing was assessed. Furthermore, the role of calcium-activated potassium channels in the power spectra was evaluated.
Methods: Analysis was performed using Matlab. Power spectral density (PSD) of PCs output were obtained. Peak frequencies were extracted from the spectrum and statistical comparisons were done. In addition, a multi-compartment computational model of a Purkinje cell was used. This computational stimulation allowed us to study the changes in the power spectral density of the PC output as a result of alteration in ion channels.
Results: Spectral analysis showed that in the spectrum of tonic and burst firing pattern only high sodium frequency and low calcium frequency was seen, respectively. In addition, there was a significant difference between the frequency components of PCs firing obtained from normal, ataxia and riluzole treated rats. Results indicated that sodium firing frequency of normal, ataxic and treated PCs occurred in approximate frequency of 22.53±5.49, 6.46±0.23, and 31.34±4.07 Hz, respectively; and calcium frequency occurred in frequency of 4.22±2.02, 1.52±1.19, and 3.88±1.37 Hz, respectively. The simulation results demonstrated that blockade of calciumactivated potassium channels in the PC model changed the PSD of the PC model firing activity. This change was similar to PSD changes in ataxia condition.
Conclusion: These alterations in the spectrum of PC output may be a basis for developing possible new treatment strategies to improve cerebellar ataxia.
Cerebellar ataxias, Purkinje cells, Calcium spike, Sodium spike, Signal processing
61
68
http://bcn.iums.ac.ir/browse.php?a_code=A-10-188-2&slc_lang=en&sid=1
2016/05/132016/04/192016/05/62016/01/172016/06/172016/01/22016/02/262016/05/11
1395/2/22
2016/09/102016/07/52016/09/12016/05/272016/11/292016/04/162016/08/222016/09/30
1395/7/9
Samira
Abbasi
Computational Neuroscience Laboratory, Department of Biomedical Engineering, Faculty of Electrical Engineering, Sahand University of Technology, Tabriz, Iran.
samira.abbasi@gmail.com
00319475328460010018
00319475328460010018
No
Ataollah
Abbasi
Computational Neuroscience Laboratory, Department of Biomedical Engineering, Faculty of Electrical Engineering, Sahand University of Technology, Tabriz, Iran.
ata.abbasi@gmail.com
00319475328460010019
00319475328460010019
Yes
Yashar
Sarbaz
Department of Mechatronics, School of Engineering- Emerging Technologies, University of Tabriz, Tabriz, Iran.
yashar22c@yahoo.com
00319475328460010020
00319475328460010020
No
Mahyar
Janahmadi
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Janahmadi@sbmu.ac.ir
00319475328460010021
00319475328460010021
No
en
The Effect of Group-Based Occupational Therapy on Performance and Satisfaction of Stroke Survivors: Pilot Trail, Neuro-Occupational View
Introduction: Stroke imposes limitations on performing activities of daily living (ADL) and their level. Different therapeutic approaches are used for improving the level of performance after a stroke. This study was performed with the aim of evaluating the effect of group-based occupational therapy on improving the performance of ADL and satisfaction of its performance in patients with chronic strokes.
Methods: Fourteen chronic stroke patients with the mean age of 52 years participated in the study. The participants were assigned into two groups (control and treatment). The level of performance of ADL, level of stroke disability, and participation were respectively evaluated by Barthel index (BI), modified Rankin scale (MRS), and Canadian Occupational Performance Measure (COPM). Six sessions of group therapy tasks were scheduled with an emphasis on three main activities, including mobility exercises, craft, and cooking.
Results: The COPM changes in the ‘performance’ and ‘satisfaction’ scores in the treatment group and the ‘performance’ scores in the control group were significant. The MRS scale in the two groups revealed no change in the level of stroke disability. However, the changes in the ADL performance in BI were significant.
Conclusion: The current study indicated that doing daily, craft, and mobility activities in the groups can affect the ‘performance’ and ‘satisfaction’ levels in stroke patients.
Stroke, Performance and satisfaction, Neurooccupational
69
76
http://bcn.iums.ac.ir/browse.php?a_code=A-10-857-1&slc_lang=en&sid=1
2016/05/132016/04/192016/05/62016/01/172016/06/172016/01/22016/02/262016/05/112016/06/12
1395/3/23
2016/09/102016/07/52016/09/12016/05/272016/11/292016/04/162016/08/222016/09/302016/11/18
1395/8/28
Maryam
Mehdizadeh
Department of neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
maryam.mehdizadeh_22@yahoo.com
00319475328460010022
00319475328460010022
No
Afsoon
Hassani Mehraban
Department of Occupational Therapy, Rehabilitation Research Center, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
mehraban.a@iums.ac.ir
00319475328460010023
00319475328460010023
Yes
Roohollah
Zahediyannasab
Department of Occupational Therapy, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
roohollah1991@yahoo.com
00319475328460010024
00319475328460010024
No
en
Neuroprotective Effects of Exercise on Brain Edema and Neurological Movement Disorders Following the Cerebral Ischemia and Reperfusion in Rats
Introduction: Cerebral ischemia and reperfusion causes physiological and biochemical changes in the neuronal cells that will eventually lead to cell damage. Evidence indicates that exercise reduces the ischemia and reperfusion-induced brain damages in animal models of stroke. In the present study, the effect of exercise preconditioning on brain edema and neurological movement disorders following the cerebral ischemia and reperfusion in rats was investigated.
Methods: Twenty-one adult male wistar rats (weighing 260-300 g) were randomly divided into three groups: sham operated, exercise plus ischemia, and ischemia group (7 rats per group). The rats in exercise group were trained to run on a treadmill 5 days a week for 4 weeks. Transient focal cerebral ischemia and reperfusion were induced by middle cerebral artery occlusion (MCAO) for 60 minutes, followed by reperfusion for 23 hours. After 24 hours ischemia, movement disorders were tested by a special neurological examination. Also, cerebral edema was assessed by determining the brain water content.
Results: The results showed that pre-ischemic exercise significantly reduced brain edema (P<0.05). In addition, exercise preconditioning decreased the neurological movement disorders caused by brain ischemia and reperfusion (P<0.05).
Conclusion: Preconditioning by exercise had neuroprotective effects against brain ischemia and reperfusion-induced edema and movement disorders. Thus, it could be considered as a usefulstrategy for prevention of ischemic injuries, especially in people at risk.
Exercise, Preconditioning, Edema, Movement disorders, Ischemia and reperfusion
77
84
http://bcn.iums.ac.ir/browse.php?a_code=A-10-766-2&slc_lang=en&sid=1
2016/05/132016/04/192016/05/62016/01/172016/06/172016/01/22016/02/262016/05/112016/06/122016/06/16
1395/3/27
2016/09/102016/07/52016/09/12016/05/272016/11/292016/04/162016/08/222016/09/302016/11/182016/11/8
1395/8/18
Nabi
Shamsaei
Department of Physical Education, Faculty of Literature and Humanities, Ilam University, Ilam, Iran.
shamsaeinabi@gmail.com
00319475328460010025
00319475328460010025
Yes
Soheila
Erfani
Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
sohailaerfani@gmail.com
00319475328460010026
00319475328460010026
No
Masoud
Fereidoni
Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
fereidoni@um.ac.ir
00319475328460010027
00319475328460010027
No
Ali
Shahbazi
Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
shahbazial@yahoo.com
00319475328460010028
00319475328460010028
No
en
Commentary: Comment on the Effect of Endocannabinoid System on Rat Behavior
I read the recently published article in Vol 6 (3) of Basic and Clinical Neuroscience entitled “Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus- Maze” by Komaki et al. (2015). In this valuable article, the authors uncovered the effects of AM251 as a CB1 receptor antagonist on anxiety-like behaviors of rats using elevated plus-maze
Endocannabinoid System
85
86
http://bcn.iums.ac.ir/browse.php?a_code=A-10-798-1&slc_lang=en&sid=1
2016/05/132016/04/192016/05/62016/01/172016/06/172016/01/22016/02/262016/05/112016/06/122016/06/162016/05/11
1395/2/22
2016/09/102016/07/52016/09/12016/05/272016/11/292016/04/162016/08/222016/09/302016/11/182016/11/82016/11/15
1395/8/25
Ali
Roohbakhsh
Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
roohbakhsha@mums.ac.ir
00319475328460011418
00319475328460011418
Yes