en Original Original <b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Introduction: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">It has shown that listening to Mozart music can potentiate spatial tasks in human and reduce seizure attacks in epileptic patients. A few studies have reported the effects of prenatal plus postpartum exposure of mice to the Mozart music on brain-drived neurotrophic factor (BDNF) in the hippocampus. Here we investigated the effect of postpartum exposure to The Mozart music on BDNF </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">concentration in the hippocampus of rat.</font></font></font><b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Methods: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">Thirty male one day old newborn Wistar rats divided randomly in </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">two equal experimental and control groups. Experimental group exposed to slow rhythm Mozart music (Mozart Sonata for two pianos KV 448, 6 hour per day sound pressure levels, between 80 and 100 dB) for 60 successive days. The control group was kept in separate room with housing conditions like experimental group except music exposure. After 60 days the rats were euthanized and hippocampuses extracted then the content of BDNF protein was measured using ELISA sandwich </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">method. </font></font></font><b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Results: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">Data analysis revealed that rats exposed to Mozart Sonata music had significantly increased BDNF content in the hippocampus as compared to control rats (P</font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">±</font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">0.01). The concentrations of BDNF were 86.30±2.26 and 94.60 ±6.22 ng/g wet weight in control and music exposure groups respectively.</font></font></font><b><font color="#211d1e" size="2"><font color="#211d1e" size="2"><p align="left">Discussion: </p></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">Exposure to the Mozart music early in life can increase the BDNF </font></font></font><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman"><font color="#211d1e" size="2" face="Times New Roman,Times New Roman">concentration in the hippocampus in rats. </font></font></font></b></b></b></b> Mozart Music,BDNF,Hippocampus,Rat 21 26 http://bcn.iums.ac.ir/browse.php?a_code=A-10-8-3&slc_lang=en&sid=1 Mohsen Marzban 137003194753284600945 137003194753284600945 Yes Ali Shahbazi 137003194753284600946 137003194753284600946 No Mahdi Tondar 137003194753284600947 137003194753284600947 No Mansooreh Soleimani 137003194753284600948 137003194753284600948 No Masoomeh Bakhshayesh 137003194753284600949 137003194753284600949 No Arash Moshkforoush 137003194753284600950 137003194753284600950 No Mehdi Sadati 137003194753284600951 137003194753284600951 No Siamak Alizadeh Zendehrood 137003194753284600952 137003194753284600952 No Mohammad Taghi Joghataei 137003194753284600953 137003194753284600953 No