Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1390
6
1
gregorian
2011
9
1
2
2
online
1
fulltext
en
The Effect of Acute Ethanol and Gabapentin Administration on Spatial Learning and Memory
Original
Original
<p align="left" ><p align="justify"> <b><font color="#221e1f" size="2">Introduction: </font><font face="Times New Roman,Times New Roman" color="#221e1f" size="2">Patients with epilepsy can have impaired cognitive abilities. Many factors contribute to this impairment, including the adverse effects of antiepileptic drugs like Gabapentin (GBP). Apart from anti-epilectic action, Gabapentin is used to relieve ethanol withdrawal syndrome. Because both GBP and ethanol act on GABA ergic system, the purpose of this study was to evaluate their effect and interaction on spatial learning and memory. </font><b><font color="#221e1f" size="2"><p align="justify">Material and Methods: </p></font><font face="Times New Roman,Times New Roman" color="#221e1f" size="2">Male Sprague-Dawley rats were trained in the Morris water maze for 5 consecutive days. On the sixth day, a probe test was performed to assess the retention phase or spatial rats’ memory ability. Ethanol (1.5 g/kg i.p.) and GBP (30 mg/kg i.p.) was administered each day 30 and 40 minutes before testing respectively. </font><b><font color="#221e1f" size="2"><p align="justify">Results: </p></font><font face="Times New Roman,Times New Roman" color="#221e1f" size="2">Acute ethanol administration selectively impaired spatial memory (p<0.05), yet it failed to impair the acquisition phase (learning). Contradictorily GBP selectively impaired learning on second and forth days. </font><b><font color="#221e1f" size="2"><p align="justify">Conclusion: </p></font><font face="Times New Roman,Times New Roman" color="#221e1f" size="2">These findings demonstrate that GBP and acute ethanol impair </font><font face="Times New Roman,Times New Roman" color="#221e1f" size="2">different phases of learning probably by modifying different neuronal pathways in cognitive areas of the brain. </font></b></b></b></b></p>
Spatial Memory,Leraning,Acute Ethanol,Gabapentin
44
47
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2-20&slc_lang=en&sid=1
Fahimeh
Yeganeh
137003194753284600630
137003194753284600630
Yes
Farnaz
Nikbakht
137003194753284600631
137003194753284600631
No
Homa
Rasouli
137003194753284600632
137003194753284600632
No