fa Behavioral Neuroscience Behavioral Neuroscience Original Original <p style="text-align: justify;"><strong>Introduction:</strong> We evaluated the incidence and clinical outcome of patients with hypertensive acute ischemic stroke (AIS) admitted to a tertiary care center in Central India. In addition, we examined the status of stroke biomarkers namely neuron-specific enolase (NSE), glial specific protein (S-100&beta;&beta;), and inter-&alpha;-trypsin inhibitor heavy chain 4(ITIH4) in the serum of patients suffering from AIS with hypertension (HTN) and without HTN.<br> <strong>Methods:</strong> A total of 104 patients with AIS were enrolled for the study. Clinical outcome and stroke biomarker levels were evaluated in them at the time of hospital discharge and then followed at 12 months and 18 months after hospital discharge.&nbsp;<br> <strong>Results:</strong> HTN is a major risk factor associated with 67%(70.104) of patients with AIS. Multivariate analysis suggests higher odds of 4.088(95%Cl, 0.721&ndash;23.179) and 2.437(95%Cl, 0.721&ndash;23.179) for 12 and 18 months outcome in patients with AIS and HTN, respectively. Serum NSE and S-100&beta;&beta; decreased at the time of discharge as compared to admission level in improved patients suffering from AIS with or without HTN, whereas levels of ITIH4 peptides 2 and 7 increased at the time of discharge (compared to its admission level) only in improved patients with AIS regardless of HTN or non-HTN condition.<br> <strong>Conclusion: </strong>HTN is one of the major risk factors associated with higher risk of AIS as well as long-term unfavourable outcome after AIS in Central India region. NSE, S-100&beta;&beta;, and ITIH4 were found to be independent predictors of outcome in patients with AIS irrespective of HTN and non-HTN condition.</p> Hypertension, Acute ischemic stroke, Biomarkers, ITIH4 protein, Neuron specific enolase, S-100ββ 351 360 http://bcn.iums.ac.ir/browse.php?a_code=A-10-992-9&slc_lang=fa&sid=1 Amit R. Nayak 1370031947532846008568 1370031947532846008568 No Biochemistry Research Centre, Central India Institute of Medical Sciences, Maharashtra, India Seema D. Shekhawat 1370031947532846008569 1370031947532846008569 No Biochemistry Research Centre, Central India Institute of Medical Sciences, Maharashtra, India Neha H. Lande 1370031947532846008570 1370031947532846008570 No Biochemistry Research Centre, Central India Institute of Medical Sciences, Maharashtra, India Anuja P. Kawle 1370031947532846008571 1370031947532846008571 No Biochemistry Research Centre, Central India Institute of Medical Sciences, Maharashtra, India Dinesh P. Kabra 1370031947532846008572 1370031947532846008572 No Biochemistry Research Centre, Central India Institute of Medical Sciences, Maharashtra, India Nitin H. Chandak 1370031947532846008573 1370031947532846008573 No Biochemistry Research Centre, Central India Institute of Medical Sciences, Maharashtra, India Shweta R. Badar 1370031947532846008574 1370031947532846008574 No MDS Bio-Analytics Private Limited, First Floor, Sakar Enclave, 127, Shankar Nagar, Nagpur: 440010, Maharashtra, India. Dhananjay V. Raje 1370031947532846008575 1370031947532846008575 No Biochemistry Research Centre, Central India Institute of Medical Sciences, Maharashtra, India Hatim F. Daginawala 1370031947532846008576 1370031947532846008576 No Biochemistry Research Centre, Central India Institute of Medical Sciences, Maharashtra, India Rajpal S. Kashyap raj_ciims@rediffmail.com 1370031947532846008577 1370031947532846008577 Yes Biochemistry Research Centre, Central India Institute of Medical Sciences, Maharashtra, India