Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1396
4
1
gregorian
2017
7
1
8
4
online
1
fulltext
fa
Effect of Mild Cognitive Impairment and Alzheimer Disease on Auditory Steady-State Responses
Cognitive Neuroscience
Cognitive Neuroscience
Original
Original
<p style="text-align: justify;"><strong>Introduction:</strong> Mild Cognitive Impairment (MCI), a disorder of the elderly people, is difficult to diagnose and often progresses to Alzheimer Disease (AD). Temporal region is one of the initial areas, which gets impaired in the early stage of AD. Therefore, auditory cortical evoked potential could be a valuable neuromarker for detecting MCI and AD. <br>
<strong>Methods: </strong>In this study, the thresholds of Auditory Steady-State Response (ASSR) to 40 Hz and 80 Hz were compared between Alzheimer Disease (AD), MCI, and control groups. A total of 42 patients (12 with AD, 15 with MCI, and 15 elderly normal controls) were tested for ASSR. Hearing thresholds at 500, 1000, and 2000 Hz in both ears with modulation rates of 40 and 80 Hz were obtained.<br>
<strong>Results:</strong> Significant differences in normal subjects were observed in estimated ASSR thresholds with 2 modulation rates in 3 frequencies in both ears. However, the difference was significant only in 500 Hz in the MCI group, and no significant differences were observed in the AD group. In addition, significant differences were observed between the normal subjects and AD patients with regard to the estimated ASSR thresholds with 2 modulation rates and 3 frequencies in both ears. A significant difference was observed between the normal and MCI groups at 2000 Hz, too. An increase in estimated 40 Hz ASSR thresholds in patients with AD and MCI suggests neural changes in auditory cortex compared to that in normal ageing. <br>
<strong>Conclusion:</strong> Auditory threshold estimation with low and high modulation rates by ASSR test could be a potentially helpful test for detecting cognitive impairment.</p>
Alzheimer disease, Auditory Steady-State Response (ASSR), Auditory ageing, Mild cognitive impairment, MCI detection
299
306
http://bcn.iums.ac.ir/browse.php?a_code=A-10-920-1&slc_lang=fa&sid=1
Elaheh
Shahmiri
elaheh_shahmiri@yahoo.com
13700319475328460010886
13700319475328460010886
No
Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zahra
Jafari
13700319475328460010887
13700319475328460010887
No
Department of Basic Sciences, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
Maryam
Noroozian
13700319475328460010888
13700319475328460010888
No
Department of Psychiatry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Azadeh
Zendehbad
13700319475328460010889
13700319475328460010889
No
Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Hassan
Haddadzadeh Niri
13700319475328460010890
13700319475328460010890
No
Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
Ali
Yoonessi
elaheh_shahmiri@yahoo.com
13700319475328460010891
13700319475328460010891
Yes
Research Center for Cognitive and Behavioral Sciences, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.