en Cognitive Neuroscience Cognitive Neuroscience Original Original <p style="text-align: justify;"><strong>Introduction:</strong> The Alzheimer Disease (AD) is the most common form of dementia that leads to memory impairment. As the oxidative stress plays an important role in AD pathogenesis, the current study aimed at examining the protective effects of Cyperus Rotundus as an antioxidant on amyloid &beta; (A&beta;) -induced memory impairment. &nbsp;<br> <strong>Methods:</strong> Twenty-eight Wistar male rats received intrahippocampal (IHP) injection of the A&beta; (1-40) and C. rotundus (400 mg/kg, intraperitoneally). Spatial memory was assessed by the Morris water-maze (MWM) task.&nbsp;<br> <strong>Results: </strong>In the MWM, A&beta; (1-40) significantly increased escape latency and traveled distance (P<0.001). The administration of C. rotundus attenuated the A&beta;-induced memory impairment in the MWM task.&nbsp;<br> <strong>Conclusion:</strong> The current study findings showed that C. Rotundus could improve the learning impairment, following the A&beta; treatment, and it may lead to an improvement of AD-induced cognitive dysfunction.</p> Alzheimer disease, Amyloid β-peptide, Cyperus rotundus, Spatial memory 249 254 http://bcn.iums.ac.ir/browse.php?a_code=A-10-438-2&slc_lang=en&sid=1 Mehdi Mehdizadeh 13700319475328460010345 13700319475328460010345 No Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran. Fataneh Hashem Dabaghian 13700319475328460010346 13700319475328460010346 No Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran. Asie Shojaee 13700319475328460010347 13700319475328460010347 No Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran. Nima Molavi 13700319475328460010348 13700319475328460010348 No Department of Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Zahra Taslimi 13700319475328460010349 13700319475328460010349 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamedan, Iran. Ronak Shabani 13700319475328460010350 13700319475328460010350 No Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Sara Soleimani Asl s.soleimaniasl@umsha.ac.ir 13700319475328460010351 13700319475328460010351 Yes Endometrium and Endometriosis Research Center, Hamedan University of Medical Sciences, Hamedan, Iran.