Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1393
11
1
gregorian
2015
2
1
6
1
online
1
fulltext
en
Evaluation of Hemodynamic Response Function in Vision and Motor Brain Regions for the Young and Elderly Adults
Computational Neuroscience
Computational Neuroscience
Original
Original
<b>
Introduction: </b>Prior studies comparing Hemodynamic Response Function (HRF) in the young
and elderly adults based on fMRI data have reported inconsistent findings for brain vision and
motor regions in healthy aging. It is shown that the averaging method employed in all previous
works has caused this inconsistency. The averaging is so sensitive to outliers and noise. However,
fMRI data are obscured with a major contribution of noise particularly in the elderly case. <div><b>Methods:</b> Deconvolution algorithm is here proposed for HRF extraction to achieve more
robustness against noise. In spite of earlier works, proposed deconvolution algorithm yields
compatible HRF results using either original or denoised fMRI data, though a large percentage
of selected active voxels change in the latter case. In the current study, event-related fMRI
data have been used for 18 subjects (8 young and 10 elderly adults) with a simple visual and
motor task of pressing a key with index in response to the visual presentation of the word tap.
Considering anatomically-defined vision and motor regions and preprocessing steps in FSL and
SPM, the activated voxels have been selected according to t-test for which HRF is estimated
using deconvolution method. </div><div><b>Results: </b>Experimental results demonstrate that HRF peak amplitudes do not differ significantly
(p=0.8) in the vision region for the young and the elderly. In motor region, the HRF peak
significantly increases for the young compared to the elderly (p<0.03). Repeating the procedure
on the denoised fMRI data using MDL algorithm, the same results have been obtained. </div><div><b>Discussion: </b>In this study, a comparative study has been realized on the hemodynamic
response properties associated with the young and the elderly adults on a simple visual
and motor task.
</div>
Aging, Hemodynamic Response Function, fMRI, Denoising, MDL
58
68
http://bcn.iums.ac.ir/browse.php?a_code=A-10-564-2&slc_lang=en&sid=1
Hassan
Morsheddost
hmorsheddost@ee.kntu.ac.ir
1370031947532846005494
1370031947532846005494
No
KNTU
Davud
Asemani
Asemani@eetd.kntu.ac.ir
1370031947532846005495
1370031947532846005495
Yes
KNTU
Mahsa
Alizadeh
ma.shalchy@ee.kntu.ac.ir
1370031947532846005496
1370031947532846005496
No
KNTU