en Cellular and molecular Neuroscience Cellular and molecular Neuroscience Review Review <p dir="ltr" style="text-align: justify;"><strong>Introduction:</strong> Transforming Growth Factor-Beta 1 (TGF-&beta;1) is a pleiotropic cytokine with&nbsp;potent anti-inflammatory property, which has been considered as an essential risk factor in the&nbsp;inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression&nbsp;of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF-&beta;1 gene polymorphism&nbsp;has been found to be associated with the risk of IS. The aim of this meta-analysis was to provide&nbsp;a relatively comprehensive account of the relation between -509C/T gene polymorphisms of&nbsp;TGF-&beta;1 and susceptibility to IS.<br> <strong>Methods:</strong> A review of literature for eligible genetic association Studies published before October&nbsp;20, 2014 was conducted in the PubMed, EMBASE, Google Scholar and Trip database. The&nbsp;strength of association was calculated by pooled odds ratios (ORs) with 95% confidence intervals&nbsp;using RevMan 5.3 software. Heterogeneity was examined using Higgins I-squared, Tau-squared,&nbsp;and Chi-squared tests.<br> <strong>Results: </strong>A total of 2 studies involving 614 cases and 617 controls were found. The overall&nbsp;estimates did not show any significant relation between TGF-&beta;1-509C/T polymorphism and risk&nbsp;of IS under dominant (CC+CT vs. TT: OR=1.01, 95%CI=0.31 to 3.26; P=0.99), recessive (CC&nbsp;vs. CT+TT: OR=0.94, 95%CI=0.47 to 1.90; P=0.87), and allelic models (T vs. C: OR=1.06,&nbsp;95%CI=0.55 to 2.04; P=0.86).<br> <strong>Conclusion:</strong> This meta-analysis showed that TGF-&beta;1-509C/T gene polymorphism no significant&nbsp;association with the susceptibility of IS. Further well-designed prospective studies with larger&nbsp;sample size are needed to confirm these findings.</p> Transforming growth factor beta, Cytokine, Inflammation, Cerebral infarction, Ischemic stroke, Single nucleotide polymorphism, Metaanalysis 91 96 http://bcn.iums.ac.ir/browse.php?a_code=A-10-669-1&slc_lang=en&sid=1 Pradeep Kumar pradeephuptaneuro@gmail.com 1370031947532846007392 1370031947532846007392 No Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Amit Kumar amits52003@gmail.com 1370031947532846007393 1370031947532846007393 No Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Mukesh Kumar Srivastava sriwastva.mukesh6@gmail.com 1370031947532846007394 1370031947532846007394 No Department of Neurobiochemistry, All India Institute of Medical Sciences, New Delhi, India. Shubham Misra 1370031947532846007395 1370031947532846007395 No Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Kameshwar Prasad kp0704@gmail.com 1370031947532846007396 1370031947532846007396 Yes Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Awadh Kishor Pandit akpandit.med@gmail.com 1370031947532846007397 1370031947532846007397 No Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.