en Behavioral Neuroscience Behavioral Neuroscience Original Original <p dir="ltr" style="text-align: justify;"><strong>Introduction:</strong> Transforming Growth Factor-Beta 1 (TGF-&beta;1) is a pleiotropic cytokine with&nbsp;potent anti-inflammatory property, which has been considered as an essential risk factor in the&nbsp;inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression&nbsp;of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF-&beta;1 gene polymorphism&nbsp;has been found to be associated with the risk of IS. The aim of this meta-analysis was to provide&nbsp;a relatively comprehensive account of the relation between -509C/T gene polymorphisms of&nbsp;TGF-&beta;1 and susceptibility to IS.<br> <strong>Methods:</strong> Male Wistar rats were divided into sham (receiving phosphate buffered saline within&nbsp;dorsal hippocampus), pilocarpine (epileptic model of TLE), single injection BDNF (epileptic rats&nbsp;which received single high dose of BDBF within dorsal hippocampus), and multiple injections&nbsp;BDNF (epileptic rats which received BDNF in days 10, 11, 12, and 13 after induction of TLE)&nbsp;groups. Their electrocorticogram was recorded and amplitude, frequency, and duration of spikes&nbsp;were evaluated.<br> <strong>Results</strong>: Amplitude and frequency of epileptiform burst discharges were significantly decreased&nbsp;in animals treated with BDNF compared to pilocarpine group.<br> <strong>Conclusion</strong>: Our findings suggested that BDNF may modulate the epileptic activity in the&nbsp;animal model of TLE. In addition, it may have therapeutic effect for epilepsy. More studies are<br> necessary to clarify the exact mechanisms of BDNF effects.</p> Temporal lobe epilepsy, BDNF, EEG, Brain, Rat 115 120 http://bcn.iums.ac.ir/browse.php?a_code=A-10-337-1&slc_lang=en&sid=1 Sanaz Eftekhari sanaz.eftekhari8@gmail.com 13700319475328460014602 13700319475328460014602 No Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Soraya Mehrabi soraya.mehrabi@gmail.com 13700319475328460014603 13700319475328460014603 No Shefa Neuroscience Center, Khatam-Alanbia Hospital, Tehran, Iran. Fariba Karimzadeh fariba_karimzade@yahoo.com 13700319475328460014604 13700319475328460014604 No Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Mohammad-Taghi Joghataei mt.joghataei@yahoo.com 13700319475328460014605 13700319475328460014605 No Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. Mojtaba Khaksarian 13700319475328460014606 13700319475328460014606 No Department of Physiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. Mahmoud Reza Hadjighassem 13700319475328460014607 13700319475328460014607 No Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Majid Katebi 13700319475328460014608 13700319475328460014608 No Department of Anatomy, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Mansooreh Soleimani mansourehsoleimani@gmail.com 13700319475328460014609 13700319475328460014609 Yes Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.