Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1393
4
1
gregorian
2014
7
1
5
3
online
1
fulltext
en
Interaction between Antagonist of Cannabinoid Receptor and Antagonist of Adrenergic Receptor on Anxiety in Male Rat
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<p><strong>Introduction:</strong> Anxiety is among the most common and treatable mental disorders. Adrenergic and cannabinoid systems have an important role in the neurobiology of anxiety. The elevated plus-maze (EPM) has broadly been used to investigate anxiolytic and anxiogenic compounds. The present study investigated the effects of intraperitoneal (IP) injection of cannabinoid CB1 receptor antagonist (AM251) in the presence of alpha-1 adrenergic antagonist (Prazosin) on rat behavior in the EPM.</p>
<p><strong>Methods:</strong> In this study, the data were obtained from male Wistar rat, which weighing 200- 250 g. Animal behavior in EPM were videotaped and saved in computer for 10 min after IP injection of saline, AM251 (0.3 mg/kg), Prazosin (0.3 mg/kg) and AM251 + Prazosin, subsequently scored for conventional indices of anxiety. During the test period, the number of open and closed arms entries, the percentage of entries into the open arms of the EPM, and the spent time in open and closed arms were recorded. Diazepam was considered as a positive control drug with anxiolytic effect (0.3, 0.6, 1.2 mg/kg).</p>
<p><strong>Results:</strong> Diazepam increased the number of open arm entries and the percentage of spent time on the open arms. IP injection of AM251 before EPM trial decreased open arms exploration and open arm entry. Whereas, Prazosin increased open arms exploration and open arm entry. This study showed that both substances in simultaneous injection have conflicting effects on the responses of each of these two compounds in a single injection.</p>
<p><strong>Discussion:</strong> Injection of CB1 receptor antagonist may have an anxiogenic profile in rat, whereas adrenergic antagonist has an anxiolytic effect. Further investigations are essential for better understanding of anxiolytic and anxiogenic properties and neurobiological mechanisms of action and probable interactions of the two systems.</p>
Cannabinoid Receptor,Antagonist, Adrenergic,Antagonist,Elevated Plus-maze,Diazepam,Rat,Anxiety.
218
224
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-211&slc_lang=en&sid=1
Alireza
Komaki
13700319475328460022243
13700319475328460022243
No
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Fatemeh
Abdollahzadeh
13700319475328460022244
13700319475328460022244
Yes
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Abdolrahman
Sarihi
13700319475328460022245
13700319475328460022245
No
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Siamak
Shahidi
13700319475328460022246
13700319475328460022246
No
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Iraj
Salehi
13700319475328460022247
13700319475328460022247
No
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.