en Behavioral Neuroscience Behavioral Neuroscience Original Original <p>In the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. In this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. However, no positive results obtained in drug addiction treatment. It seems that more brain systems other than brain reward system must be considered in this regard.</p> Addiction, Reward System, Stress System 96 97 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-201&slc_lang=en&sid=1 Mina Ranjbaran 1370031947532846006469 1370031947532846006469 No Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran. * Corresponding Author: Hedayat Sahraei1, PhD. Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran. Tel: +98-21- 26127286 E-mail: h.sahraei@bmsu.ac.ir In the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. In this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. However, no positive results obtained in drug addiction treatment. It seems that more brain systems other than brain reward system must be considered in this regard. Article info: Hedayat Sahraei 1370031947532846006470 1370031947532846006470 Yes Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran. * Corresponding Author: Hedayat Sahraei1, PhD. Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran. Tel: +98-21- 26127286 E-mail: h.sahraei@bmsu.ac.ir In the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. In this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. However, no positive results obtained in drug addiction treatment. It seems that more brain systems other than brain reward system must be considered in this regard. Article info: