Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1393
8
1
gregorian
2014
11
1
5
4
online
1
fulltext
en
Modulatory Effects of Dopamine D2 Receptors on Spreading Depression in Rat Somatosensory Neocortex
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
Introduction: Spreading depression (SD) is a propagating wave of depolarization followed by depression of the neuroglial activities and can modulate extracellular dopamine concentrations in the neocortex. It has been shown that the dopaminergic system plays a role in migraine. SD has been suggested as a critical phenomenon in the pathophysiology of migraine. The aim of this study was to investigate the effect of dopamine D2 receptors on the characteristic features of SD in rat neocortical tissues.
Methods: The effect of dopamine D2 receptor agonist quinpirole and D2 receptor antagonist sulpiride was tested on different characteristic features (amplitude, duration and velocity) of KCl-induced SD in somatosensory neocortical slices of adult rats. The effect of above-mentioned substances on production of long-term potentiation (LTP) in the neocortex was also evaluated.
Results: The present data revealed a dose-dependent suppression of the amplitude and duration of SD in the presence of the dopamine D2 receptor antagonist sulpiride in the neocortex. D2 dopamine receptor agonist quinpirole dose-dependently enhanced the amplitude and duration of the neocortical SD. Furthermore, application of D2 receptor antagonist significantly suppressed induction of LTP.
Discussion: These results indicate that D2 receptors modulate the initiation of SD in the neocortex. This finding refers to the potential role of D2 receptor antagonist in treatment of migraine pain.
Spreading, Depolarization, Migraine, Stroke, Synapse, In Vitro
246
252
http://bcn.iums.ac.ir/browse.php?a_code=A-10-535-1&slc_lang=en&sid=1
Anna Maria
Haarmann
1370031947532846005422
1370031947532846005422
No
Institute of Neurophysiology, Westfälische Wilhelms-Universität Münster, Germany.
Maryam
Jafarian
gorjial@uni-muenster.de
1370031947532846005423
1370031947532846005423
No
Shefa Neuroscience Research Center, Tehran, Iran.
Fariba
Karimzadeh
1370031947532846005424
1370031947532846005424
No
School of Advanced Medical Technology, Tehran University of Medical Sciences, Tehran, Iran.
Ali
Gorji
gorjial@uni-muenster.de
1370031947532846005425
1370031947532846005425
Yes
Epilepsy Research Center, Westfälische Wilhelms-Universität Münster, Germany.