en Behavioral Neuroscience Behavioral Neuroscience Original Original <p>Introduction: Tanacetum sonbolii (Asteraceae) is an endemic species in Iran. In the present study, we examined the effects of Tanacetum sonbolii hydroalcoholic extract on the formalin test in mice. Methods: 126 Swiss albino mice weighing 230-280g were used as subjects. The formalin test was performed on two control groups (marked as intact and saline groups n = 6 in each group) and an experimental group. In all groups, the formalin test was recorded for 60 min after administration of extract and drugs in mice. Results: The results showed that Tanacetum sonbolii (150 and 300 mg/kg) produced significant antinociception in phase 2. In addition, different doses of Tanacetum sonbolii extract (600, 900 and 1200 mg/kg) also induced antinociceptive effects in phase1 and phase 2. On the other hand, morphine could induce antinociception in a dose-dependent manner. Diclofenac (10 mg/kg) failed to affect the pain scores compared to Tanacetum sonbolii (300 mg/kg) group. Discussion: It seems that administration of hydroalcoholic extract of Tanacetum sonbolii has the potential to relieve pain through both central and peripheral mechanisms in persistent inflammatory nociception.</p> Tanacetumsonbolii (Asteraceae), Morphine, Formalin Test, Mice 162 168 http://bcn.iums.ac.ir/browse.php?a_code=A-10-257-4&slc_lang=en&sid=1 Mohammad Sofiabadi 1370031947532846006400 1370031947532846006400 Yes Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. Hassan Azhdari Zarmehri 1370031947532846006401 1370031947532846006401 No Department of Basic Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran. Firiozeh Naderi 1370031947532846006402 1370031947532846006402 No Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. Mohhadese Ghalandri 1370031947532846006403 1370031947532846006403 No Physiology–Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Ali Sonboli 1370031947532846006404 1370031947532846006404 No Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran. Abbass Haghprast 1370031947532846006405 1370031947532846006405 No Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.