Basic and Clinical Neuroscience Journal

en Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion Cellular and molecular Neuroscience Cellular and molecular Neuroscience Original Original Introduction: Stroke is one of the most important reasons of death. Hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. The ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. The A1 adenosine receptoras an endogenous ligand of adenosine is known to improve cell resistance to destructive agentsby preventing apoptosis. Vitamin C as a cellular antioxidant is also known as an effective factor to reduce damages initiated by free radicals. We studied the protective effects of A1 receptor agonist in combination with vitamin C against ischemia-reperfusion. Methods: Ischemia was induced by common carotid artery occlusion in bulb-c mice (20-30 gr). Y-Maze was employed to scale the short-term memory and Nissl staining was used to count the cells in hippocampus. Results: We found that concurrent treatment of A1 receptor agonist and vitamin C significantly reduced neuronal death in CA1. The Memory scores were also significantly improved (P<0.05). Discussion: Our data point to the therapeutic effects of CPA/vitamin C co-administration and highlight the beneficial role of A1 adenosine receptor signaling in the context of stroke Ischemia-Reperfusion,Hippocampus,A1 receptor,Vitamin C. 111 116 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-149&slc_lang=en&sid=1 Mohmmad Zamani 1370031947532846003844 1370031947532846003844 No M. Katebi 1370031947532846003845 1370031947532846003845 No Mehdi Mehdizadeh 1370031947532846003846 1370031947532846003846 No Laya Kafami 1370031947532846003847 1370031947532846003847 No Fatemeh Malek 1370031947532846003848 1370031947532846003848 No Mansooreh Soleimani 1370031947532846003849 1370031947532846003849 Yes