Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1392
1
1
gregorian
2013
4
1
4
2
online
1
fulltext
en
Combination Therapy with A1 Receptor Agonist and Vitamin C Improved Working Memory in a Mouse Model of Global Ischemia-Reperfusion
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<p align="left" ><p><b><font color="#221e1f" size="1"><font color="#221e1f" size="1">Introduction: </font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="1"><font color="#221e1f" face="Times New Roman,Times New Roman" size="1"><font color="#221e1f" face="Times New Roman,Times New Roman" size="1">Stroke is one of the most important reasons of death. Hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. The ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. The A1 adenosine receptoras an endogenous ligand of adenosine is known to improve cell resistance to destructive agentsby preventing apoptosis. Vitamin C as a cellular antioxidant is also known as an effective factor to reduce damages initiated by free radicals. We studied the protective effects of A1 receptor agonist in combination with vitamin C against ischemia-reperfusion. </font></font></font><b><font color="#221e1f" size="1"><font color="#221e1f" size="1"><p align="justify">Methods: </p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="1"><font color="#221e1f" face="Times New Roman,Times New Roman" size="1"><font color="#221e1f" face="Times New Roman,Times New Roman" size="1">Ischemia was induced by common carotid artery occlusion in bulb-c mice (20-30 gr). Y-Maze was employed to scale the short-term memory and Nissl staining was used to count the cells in hippocampus. </font></font></font><b><font color="#221e1f" size="1"><font color="#221e1f" size="1"><p align="justify">Results: </p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="1"><font color="#221e1f" face="Times New Roman,Times New Roman" size="1"><font color="#221e1f" face="Times New Roman,Times New Roman" size="1">We found that concurrent treatment of A1 receptor agonist and vitamin C significantly reduced neuronal death in CA1. The Memory scores were also significantly improved (P<0.05). </font></font></font><b><font color="#221e1f" size="1"><font color="#221e1f" size="1"><p>Discussion: </p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="1"><font color="#221e1f" face="Times New Roman,Times New Roman" size="1"><font color="#221e1f" face="Times New Roman,Times New Roman" size="1">Our data point to the therapeutic effects of CPA/vitamin C co-administration and highlight the beneficial role of A1 adenosine receptor signaling in the context of stroke </font></font></font></b></b></b></b></p>
Ischemia-Reperfusion,Hippocampus,A1 receptor,Vitamin C.
111
116
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-149&slc_lang=en&sid=1
Mohmmad
Zamani
1370031947532846003844
1370031947532846003844
No
M.
Katebi
1370031947532846003845
1370031947532846003845
No
Mehdi
Mehdizadeh
1370031947532846003846
1370031947532846003846
No
Laya
Kafami
1370031947532846003847
1370031947532846003847
No
Fatemeh
Malek
1370031947532846003848
1370031947532846003848
No
Mansooreh
Soleimani
1370031947532846003849
1370031947532846003849
Yes