Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1391
11
1
gregorian
2013
2
1
4
1
online
1
fulltext
en
The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<p><strong> Introduction:</strong> Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects.</p>
<p><strong>Methods:</strong> For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others.</p>
<p><strong>Results:</strong> Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups.</p>
<p><strong>Discussion:</strong> These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and .nd new effective substance against this kind of epilepsy.</p>
<p></p>
Ciprofloxacin, Absence epilepsy, Wag/Rij, EEG
31
35
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-137&slc_lang=en&sid=1
Ali
Moghimi
1370031947532846006505
1370031947532846006505
Yes
The Applied Research Center for Neurofeedback and Neurobehavioral Sciences (Aren), Ferdowsi University of Mashhad, Iran
Samaneh
Mollazadeh
1370031947532846006506
1370031947532846006506
No
Biotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Science, Mashhad, Iran.
Fatemeh
Behnam Rassouli
1370031947532846006507
1370031947532846006507
No
Cell and Molecular Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
Reza
Shiee
1370031947532846006508
1370031947532846006508
No
Department of Signal and Systems, Chalmers University, Sweden.
Mohammad Ali
Khalilzade
1370031947532846006509
1370031947532846006509
No
Mohammad Ali Khalilzade