en Cellular and molecular Neuroscience Cellular and molecular Neuroscience Original Original <p><strong> Introduction:</strong> Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects.</p> <p><strong>Methods:</strong> For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others.</p> <p><strong>Results:</strong> Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups.</p> <p><strong>Discussion:</strong> These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and .nd new effective substance against this kind of epilepsy.</p> <p></p> Ciprofloxacin, Absence epilepsy, Wag/Rij, EEG 31 35 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-137&slc_lang=en&sid=1 Ali Moghimi 1370031947532846006505 1370031947532846006505 Yes The Applied Research Center for Neurofeedback and Neurobehavioral Sciences (Aren), Ferdowsi University of Mashhad, Iran Samaneh Mollazadeh 1370031947532846006506 1370031947532846006506 No Biotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Science, Mashhad, Iran. Fatemeh Behnam Rassouli 1370031947532846006507 1370031947532846006507 No Cell and Molecular Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran Reza Shiee 1370031947532846006508 1370031947532846006508 No Department of Signal and Systems, Chalmers University, Sweden. Mohammad Ali Khalilzade 1370031947532846006509 1370031947532846006509 No Mohammad Ali Khalilzade