en Behavioral Neuroscience Behavioral Neuroscience Review Review <div style="text-align: justify;"><strong>Introduction</strong>: Although damage to the visual area (V1) leads to visual impairment, some patients retain the ability to process visual information unconsciously, a phenomenon known as blindsight. This study aims to systematically review and compare the proposed neural pathways mediating blindsight in humans and monkeys, providing a structured framework for future investigations in this field.<br> <strong>Methods</strong>: This is a systematic review of related articles retrieved from online databases. Following the screening process, we employed the JBI critical appraisal checklist as well as the SYRCLE tool to assess the risk of bias in human and animal studies. We selected 25 articles focusing on the mediating pathways of blindsight.<br> <strong>Results</strong>: In humans, the pathways from the lateral geniculate nucleus (LGN) to V5, from the superior colliculus (SC) to higher brain areas, and to the remaining segments of V1 are crucial. The pathway that connects the SC, pulvinar, and amygdala is essential for processing emotional visual information. Studies conducted on monkeys emphasized the importance of the SC-pulvinar pathway and the connections between the LGN and extrastriate visual areas for developing blindsight.<br> <strong>Conclusion</strong>: Rather than a single consistent pathway, blindsight appears to involve multiple parallel routes whose engagement depends on factors such as lesion extent, individual neuroanatomy, and time since injury. Future studies should explore the therapeutic potential of these pathways by integrating.&nbsp;</div> Blindsight, Residual vision, Lateral geniculate nucleus, Superior colliculus, V1 islands 533 550 http://bcn.iums.ac.ir/browse.php?a_code=A-10-7005-1&slc_lang=en&sid=1 Mohammad Reza Balali Balalimr1376@gmail.com 13700319475328460054270 13700319475328460054270 No Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mohaddeseh Hosseini Mohadessehh@gmail.com 13700319475328460054271 0009-0000-6164-2013 No Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Maryam Khanboloki Maryam.khanboloki@gmail.com 13700319475328460054272 0009-0000-2563-1464 No Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mohammad Mohammadi Mohammadi.moh4@gmail.com 13700319475328460054273 13700319475328460054273 No Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Amir Mohammad Khorshidvand Amirmohammadkh1998@gmail.com 13700319475328460054274 0009-0001-8847-4168 Yes Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mohammad Taghi Joghataei Mt.joghataei@yahoo.com 13700319475328460054275 0009-0005-6748-6468 No Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.