en Cellular and molecular Neuroscience Cellular and molecular Neuroscience Original Original <div style="text-align: justify;"><strong>Introduction</strong>: The present study aimed to identify brain regions sensitive to emotion-specific acoustic parameters in healthy individuals.<br> <strong>Methods</strong>: Three pseudo-words in the form of one stimulus were consecutively spoken with neutral and angry prosody. Then, we changed the acoustic parameters (mean fundamental frequency [F0], intensity, and speech tempo) in angry prosody. The stimuli were presented in a functional magnetic resonance imaging experiment to detect anger or neutrality.<br> <strong>Results</strong>: Stronger activation in the left superior temporal gyrus (STG) and Heschl&rsquo;s gyrus (HG) was observed when the mean F0 converted from 300 Hz to 250 Hz. Increased activity in the right posterior STG and posterior middle temporal gyrus (MTG) was revealed in more intensity anger prosody. Moreover, we found stronger activity in the right mid-STG, MTG, and the left STG in a faster speech tempo.<br> <strong>Conclusion</strong>: According to the increased activity in the STG and MTG of both hemispheres following the more intense anger (lower fundamental frequency, more intensity, and faster speech tempo), a more intense comprehension of anger may result from the sending different information from these regions to the inferior frontal gyrus (IFG) and orbital frontal cortex (OFC).</div> Acoustic parameters, Emotional prosody, Functional magnetic resonance imaging (fMRI), Intensity, Mean F0, Speech tempo 461 474 http://bcn.iums.ac.ir/browse.php?a_code=A-10-6163-1&slc_lang=en&sid=1 Hossein Abroodi abroodi.neuro@gmail.com 13700319475328460053268 0009-0009-2732-3073 Yes Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. Mohammad Taghi Joghataei mt.joghataei@yahoo.com 13700319475328460053269 13700319475328460053269 No Department of Innovation in Medical Education, Faculty of Medicine, Ottawa University, Ontario, Canada. Ehsan Shekari Ehsanshekari66@yahoo.com 13700319475328460053270 13700319475328460053270 No Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. Reza Nilipour rnilipour@yahoo.com 13700319475328460053271 13700319475328460053271 No Department of Speech Therapy, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Vahid Valinejad Valinejad.vahid@gmail.com 13700319475328460053272 13700319475328460053272 No Department of Speech-Language Pathology, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran Mostafa Almasi Doghaee A_mostafa108@yahoo.com 13700319475328460053273 13700319475328460053273 No Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.