en Original Original <p style="line-height: 20.8px; text-align: justify;"><span style="font-size: 12px;"><strong style="line-height: 1.6em;">Introduction:&nbsp;</strong><span style="line-height: 1.6em;">A large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in Parkinson&#39;s disease (PD). Flavonoids like quercetin have been reported to prevent neuronal degeneration caused by increased oxidative burden, therefore, this study examined whether quercetin administration at a high dose would attenuate behavioral abnormalities in experimental model of PD in rat.</span></span></p> <p style="line-height: 20.8px; text-align: justify;"><span style="font-size: 12px;"><strong>Methods:&nbsp;</strong>For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with quercetin (20 mg/kg i.p.) 1 hour before surgery and treated once a day for one month. After one month, apomorphine-induced rotational behavior was measured postlesion.</span></p> <p style="line-height: 20.8px; text-align: justify;"><span style="font-size: 12px;"><strong>Results:&nbsp;</strong>Apomorphine-induced rotations were counted after 4 weeks. Quercetin administration could attenuate the rotational behavior in treated lesioned rats as compared to untreated ones.</span></p> <p style="line-height: 20.8px; text-align: justify;"><span style="font-size: 12px;"><strong>Discussion:&nbsp;</strong>Flavonoid quercetin administration for one month could attenuate behavioral abnormalities in 6-OHDA model of PD.</span></p> Quercetin, 6-Hydroxydopamine, Parkinson’s disease, Rat 30 32 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-23&slc_lang=en&sid=1 Mehdi Mehdizadeh 1370031947532846008210 1370031947532846008210 Yes Mohammad Taghi Joghataei 1370031947532846008211 1370031947532846008211 No Maliheh Nobakht 1370031947532846008212 1370031947532846008212 No Roya Aryanpour 1370031947532846008213 1370031947532846008213 No