Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1391
6
1
gregorian
2012
9
1
3
5
online
1
fulltext
en
Involvement of Nitric Oxide System on Anxiolytic-Like Behaviors Induced by Cholestasiss
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<p><strong>Introduction:</strong> The mechanisms of hepatic encephalopathy are not fully understood. Moreover, there is no comprehensive data concerning the effects of nitric oxide (NO) system on anxiolytic-like behaviors induced by bile duct ligation (BDL). </p><p><strong>Methods:</strong> Male mice weighing 25-30 g were used and anxiety-like behaviors were tested using hole-board task. </p><p><strong>Results:</strong> The data indicated that cholestasis increased the number of head-dipping but did not alter other aspects of behavior, 7 days after BDL, suggesting an anxiolytic-like response. Furthermore, the results showed that intraperitoneal (i.p.) injection of L-arginine (200 and 250 mg/kg) 15 min before testing induced anxiolytic-like behaviors in the normal animals, 4 and 7 days after BDL (considering that the dose of 200 mg in the normal mice is ineffective but is effective in the BDL mice). On the other hand, injection of L-NAME (35 and 45 mg/kg, i.p.) 15 min before testing induced anxiogenic-like behaviors in the normal animals, 4 and 7 days after BDL (the dose of 35 mg/kg in the normal mice is ineffective but is effective in the BDL mice ). Moreover, injection of ineffective doses of L-NAME (25 and 35 mg/kg, i.p.) 15 min before administration of L-arginine (250 mg/kg, i.p.) and 7 days after BDL, decreased anxiolytic-like behaviors, signi.cantly. </p><p><strong>Discussion:</strong> Cholestatic mice show anxiolytic-like behaviors suggesting the involvement of the nitric oxide system.</p>
Cholestasis, L-Arginine, L-NAME, Anxiety, Hole-bored task, Mice.
19
29
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-127&slc_lang=en&sid=1
Mohammad
Nasehi
1370031947532846002241
1370031947532846002241
Yes
Vahid
Sabouri Khanghah
1370031947532846002242
1370031947532846002242
No
Sepideh
Mirzaei Varzeghani
1370031947532846002243
1370031947532846002243
No
Mohammad-Reza
Zarrindast
1370031947532846002244
1370031947532846002244
No