Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1391
6
1
gregorian
2012
9
1
3
5
online
1
fulltext
en
Coenzyme Q10 Protects Hippocampal Neurons against Ischemia/ Reperfusion Injury via Modulation of BAX/Bcl-2 Expression
Cellular and molecular Neuroscience
Cellular and molecular Neuroscience
Original
Original
<p><strong>Introduction:</strong> Preliminary studies have con.rmed reduction in cell death following treatment with antioxidants. According to this .nding we study the relationship between consumption of CoQ10 and expression of Bax and Bcl2 in hippocampus following ischemia/reperfusion as proteins involved in cell programmed death or apoptosis. </p><p><strong>Methods:</strong> We studied the protective role of CoQ10 against ischemia-reperfusion. Experimental design includes four groups: intact, ischemic control, sham control and treatment group with CoQ10. The mice were pre-treated with CoQ10 for a week, then ischemia was induced by common carotid artery ligation and following the reduction in in.ammation (a week) the mice was treated with CoQ10. Nissl staining was applied for counting the necrotic cells of hippocampus and the western blot was performed to measure the Bax and Bcl2 expression.</p><p><strong>Results:</strong> Cell death was signi.cantly lower when mice were treated with CoQ10. Bax expression was signi.cantly high in the ischemic group but low in the treatment group, and the bcl2 expression was lower in the ischemic group than the treatment and the vehicle groups.</p><p><strong>Discussion:</strong> Ischemia for 15 minutes induced cell death in hippocampus with more potent effect on CA1. CoQ10 intake signi.cantly reduced cell death and prevented the expression of Bax while inducing an increase in expression of bcl2.</p>
CoQ10, Hippocampus, Ischemia-Reperfusion, Neuroprotective Effect.
5
10
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-125&slc_lang=en&sid=1
Mohammad
Zamani
1370031947532846002248
1370031947532846002248
No
Majid
Katebi
1370031947532846002249
1370031947532846002249
No
Mehdi
Mehdizadeh
1370031947532846002250
1370031947532846002250
No
Farzaneh
Mohamadzadeh
1370031947532846002251
1370031947532846002251
No
Mansooreh
Soleimani
1370031947532846002252
1370031947532846002252
Yes