en Cellular and molecular Neuroscience Cellular and molecular Neuroscience Review Review <div style="text-align: justify;"><strong>Introduction</strong>: The present systematic review and meta-analysis was designed to investigate platelet-rich plasma (PRP) as an effective treatment for spinal cord injury in animal models.<br> <strong>Methods</strong>: An extensive literature search was conducted using electronic databases. The included studies were summarized based on the investigated outcomes, including functional recovery and cavity size. Data were recorded as Mean&plusmn;SD. The relationships between variables and the outcomes were investigated based on the &ldquo;meta&rdquo; command in the STATA 17.0 statistical program.<br> <strong>Results</strong>: In total, 9 articles were included in the present meta-analysis. Pooled data analysis showed that administrating PRP significantly improved the motor function of animals (standardized mean differences [SMD]=1.5; 95% CI, 0.9%, 2.1%; P<0.0001). In subgroup analysis based on the severity of the injury, PRP administration significantly improved the motor function of animals in both moderate (SMD=2.59; 95% CI, 1.59%, 3.59%; P<0.0001; I2=30.22%) and severe injuries (SMD=1.22; 95% CI, 0.64%, 1.79%; P<0.0001; I2=56.35%). However, the recovery of function was significantly more in animals with moderate spinal cord injury (meta-regression coefficient=-1.36; 95% CI, -2.68%, -0.09%; P=0.035). In assessing cavity size, pooled data analysis showed that PRP administration significantly reduces cavity size (SMD=-2.2; 95% CI, -3.44%, -0.95%; P<0.0001).<br> <strong>Conclusion</strong>: This meta-analysis shows that PRP can significantly improve motor function and reduce the cavity size in animals with moderate to severe spinal cord injuries.&nbsp;</div> Spinal cord injury, Platelet-rich plasma (PRP), Functional recovery 443 454 http://bcn.iums.ac.ir/browse.php?a_code=A-10-562-2&slc_lang=en&sid=1 Amirmohammad Toloui toloui.amir@gmail.com 13700319475328460050099 13700319475328460050099 No Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Hamzah Adel Ramawad hamzahr.adel@gmail.com 13700319475328460050100 13700319475328460050100 No Department of Emergency Medicine, NYC Health & Hospitals, Coney Island, New York, United States. Nahid Aboutaleb dr.nabotaleb@gmail.com 13700319475328460050101 13700319475328460050101 No Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. Mahmoud Yousefifard yousefifard20@gmail.com 13700319475328460050102 13700319475328460050102 Yes Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.