en Clinical Neuroscience Clinical Neuroscience Original Original <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Introduction</strong>: Magnetic resonance imaging (MRI) is the preferred neuroradiologic tool for evaluating the sellar region. Pituitary adenomas account for about 15% of primary intracranial tumors. The optimal time for postoperative MRI of central nervous system neoplasms is 48 hours after surgery. Nevertheless, controversy exists regarding the timing of postoperative MRI in the sellar region. This study analyzed the sellar MRI findings of patients with pituitary adenoma at different times before and after surgery. Finally, we suggest the optimal time for postoperative sellar MRI imaging in patients with pituitary adenoma.<br> <strong>Methods</strong>: A total of 28 patients with pituitary adenoma were evaluated. All patients did four sellar MRIs. The first MRI was done before surgery, and three were done 48 hours, two weeks, and three months after the surgery. Finally, the MRI findings at different times were compared to each other.<br> <strong>Results</strong>: The pituitary gland and adenoma signals were constant at all time points. The signal of the packing material showed no differences in T1-weighted and T1-weighted with contrast sequences but showed changes in T2-weighted sequences.&nbsp;<br> <strong>Conclusion</strong>: Contrary to&nbsp;other intracranial neoplasms, there were no apparent changes in MRI signal intensity during the 3 months after surgery in patients with pituitary adenoma. There was also no superiority of one time point for performing follow-up imaging.</span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></div> Postoperative imaging, Sellar region, Pituitary adenoma 649 658 http://bcn.iums.ac.ir/browse.php?a_code=A-10-5005-1&slc_lang=en&sid=1 Mohammad Ghorbani Mohghorbani@gmail.com 13700319475328460050753 13700319475328460050753 No Department of Neurosurgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Ehsan Keykhosravi Keykhosravie@mums.ac.ir 13700319475328460050754 13700319475328460050754 No Department of Neurosurgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mohammad Hasanpour dr.m.hpr@gmail.com 13700319475328460050755 13700319475328460050755 Yes Department of Neurosurgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Ali Abbasian Ardakani Ardakani@sbmu.ac.ir 13700319475328460050756 13700319475328460050756 No Department of Radiology Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Ehsan Mohammad Hosseini dr.m.hpr@gmail.com 13700319475328460050757 13700319475328460050757 No Department of Neurosurgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.