en Clinical Neuroscience Clinical Neuroscience Original Original <div style="text-align: justify;"><strong>Introduction</strong>: Overactive bladder (OAB) is a symptom syndrome consisting of urgency, frequency, and nocturia. It is a common urologic disorder. Percutaneous posterior tibial nerve stimulation (PTNS) is a minimally invasive, well-tolerated, and effective treatment of OAB. Recently, transcutaneous PTN stimulation (TTNS) with surface electrodes has been used, which is non-invasive. This study examines and compares the efficacy of these two therapy methods.<br> <strong>Methods</strong>: In this randomized clinical trial, 44 patients with OAB were randomly assigned to PTNS and TTNS groups. In both groups, the therapeutic interventions were performed thrice a week for four weeks, 12 sessions. Incontinence quality of life questionnaire (I-QOL) and OAB symptom score (OABSS) were evaluated before the intervention, then one week and four weeks after completing the sessions.<br> <strong>Results</strong>: Of 44 patients (41 females and 3 males), the mean age of the subjects was 51.95 years in the PTNS group and 56.86 years in the TTNS group (P=0.9). In our study, the patients&rsquo; urinary symptoms and QOL improved in both groups over time. Both interventions had no significant difference (P=0.796, P=0.372, respectively).<br> <strong>Conclusion</strong>: PTNS and TTNS effectively improved patients&rsquo; symptoms of OAB and their QOL. TTNS can be considered as effective as conventional PTNS and a less invasive alternative for PTNS in OAB treatment.&nbsp;</div> Overactive bladder (OAB), Nerve stimulation, Quality of life (QOL) 499 508 http://bcn.iums.ac.ir/browse.php?a_code=A-10-4896-1&slc_lang=en&sid=1 Tannaz Ahadi ahadi.t@iums.ac.ir 13700319475328460050146 13700319475328460050146 Yes Neuromusculoskeletal Research Centre, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. Ismaeel Noori drn94778@gmail.com 13700319475328460050147 13700319475328460050147 No Neuromusculoskeletal Research Center, Iran University of Medical Sciences, Tehran, Iran. Shayesteh Khalifeh Soltani shayesteh_khalifesoltani@yahoo.com 13700319475328460050148 13700319475328460050148 No Neuromusculoskeletal Research Center, Iran University of Medical Sciences, Tehran, Iran. Pouya Ghaboosi pghaboussi@gmail.com 13700319475328460050149 13700319475328460050149 No Neuromusculoskeletal Research Center, Iran University of Medical Sciences, Tehran, Iran. Gholam Reza Raissi raissi.gh@iums.ac.ir 13700319475328460050150 13700319475328460050150 No Neuromusculoskeletal Research Centre, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.