en Cellular and molecular Neuroscience Cellular and molecular Neuroscience Original Original <p align="left" ><p>　</p><p><font color="#221e1f" size="2"><font color="#221e1f" size="2">The attempt to find out if someone is telling a lie has been of human's interest. One of the techniques which is believed to be efficient in future is fMRI (functional Magnetic Resonance Imaging), using which the changes of regional blood flow </font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">during the designed paradigm can be recorded. This method has been considered as a better technique for studying lie and deception. For investigating the neural network associated with lying and deception, a task needs to be designed in which participants are instructed to participate in a lie-like situation. In this article, frequently used tasks have been reviewed with their merits and demerits. In addition, a summary of involved neural networks related to lie and deception, according to previous studies, is provided. The goal in future studies is to allocate brain regions associated with lie and deception that are independent of features related to the chosen task. </font></font></font></p> fMRI, lie detection, deception, task design 75 83 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-123&slc_lang=en&sid=1 Maral Yeganehdoost 1370031947532846002070 1370031947532846002070 No Morteza Pishnamazi 1370031947532846002071 1370031947532846002071 No Mohammad Ali Oghabian 1370031947532846002072 1370031947532846002072 Yes