en Cellular and molecular Neuroscience Cellular and molecular Neuroscience Original Original <p align="left" ><p><font color="#221e1f" size="2"><font color="#221e1f" size="2">Anxiety symptoms have been reported to be present in many patients with diabetes mellitus. However, little is known about the effects of hyperglycemia in critical periods of the central nervous system development. We assessed locomotive, exploratory, and anxiety behaviors in adult rats that remained from infantile </font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">repeated hyperglycemia by the open field and elevated plus maze tests. Our findings showed significant hypo activity, reduced locomotive/exploratory activities, </font></font></font><font color="#221e1f" size="2"><font color="#221e1f" size="2">increased fear related behaviors, and anxiety state between hyperglycemic and control adult males and the same differences were observed among females. In </font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">addition, no significant behavioral alterations between male and female animals </font></font></font><font color="#221e1f" size="2"><font color="#221e1f" size="2">were observed. This study determined that repeated increments in daily blood sugar levels in newborns may affect neuronal functions and provide behavioral abnormalities in adults. </font></font></p> Anxiety, Elevated plus maze, Exploratory, Hyperglycemia, Locomotive, Open field. 60 67 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-122&slc_lang=en&sid=1 Malihe Moghadami 1370031947532846002060 1370031947532846002060 Yes Ali Moghimi 1370031947532846002061 1370031947532846002061 No Emad Ahangar 1370031947532846002062 1370031947532846002062 No Razieh Jalal 1370031947532846002063 1370031947532846002063 No Morteza Behnam Rassouli 1370031947532846002064 1370031947532846002064 No Naser Mahdavi Shahri 1370031947532846002065 1370031947532846002065 No