en Clinical Neuroscience Clinical Neuroscience Original Original <div style="text-align: justify;"><strong>Introduction</strong>: Sudden, unexpected death in epilepsy (SUDEP) is a substantial cause of death in patients with epilepsy. Although electroconductive disorders leading to life-threatening arrhythmia are supposed to play a crucial role, there is a paucity of knowledge in variables among the patients with drug-resistant temporal lobe epilepsy (TLE) compared to the healthy controls.<br> <strong>Methods</strong>: The current case-control study has been conducted on 50 drug-resistant TLE patients as the cases and 50 age- and gender-matched healthy subjects selected from their first-degree family members. Electrocardiographic (ECG) were taken from the cases when admitted at the hospital (baseline), immediately after a seizure incidence, and within an hour after the end of the seizure and compared with a random ECG of the controls considering parameters, including PR-, RR-, and corrected QT interval (QTc), P wave duration, and heart rate (HR) variability.<br> <strong>Results</strong>: A shorter corrected QTc interval was notified among the drug-resistant TLE patients compared to the controls (P=0.017) in the baseline taken ECGs, while the assessments immediately after the seizure revealed significant differences in terms of RR-interval (P=0.005) and HR (P=0.005). Postictal ECGs did not differ between the groups (P>0.05).<br> <strong>Conclusion</strong>: According to the findings of this study, shortened QTc interval at baseline ECGs, shortened RR interval, and increased HR during the seizure were the ECG elements that affected drug-resistant TLE patients; however, to generalize the outcomes, further studies are required.</div> Sudden unexpected death in epilepsy (SUDEP), Temporal lobe epilepsy (TLE), Cardiac arrhythmia, Electrocardiography (ECG) 441 448 http://bcn.iums.ac.ir/browse.php?a_code=A-10-4724-1&slc_lang=en&sid=1 Jafar Mehvari dr.mehvari@hotmail.com 13700319475328460053261 13700319475328460053261 No Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Zeinab Jaafari z.jafari.med86@gmail.com 13700319475328460053262 0009-0008-9100-2242 Yes Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Mohamad Zare zaremohamad23104@gmail.com 13700319475328460053263 13700319475328460053263 No Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Nasim Tabrizi nasimtabrizi@gmail.com 13700319475328460053264 13700319475328460053264 No Department of Neurology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Alireza Khosravi Farsani alikh108@yahoo.com 13700319475328460053265 13700319475328460053265 No Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.