Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1396
12
1
gregorian
2018
3
1
0
Accepted Articles
online
1
fulltext
en
Influence of Circadian Rhythm Disturbance with Mediating Role of Chronotype on Mental State, Addiction Potential, and Boredom in Medical Students
Cognitive Neuroscience
Cognitive Neuroscience
Original
Original
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Shift workers usually underwent circadian misalignment, which appears when the feeding and sleep-wake cycles are desynchronized with the temporal framework organized by the internal biological<b> </b>clock. People differ considerably in their tolerance to shift work depending on<b> </b>their chronotype. The purpose of this research was to obtain information about circadian disorders and chronotype (as a mediating variable) on consequent mental state such as impulsivity, depression, anxiety, stress, addiction potential, and boredom in students of a medical university in northeastern Iran. We study mental state in the group of individuals with circadian misalignment and compared with healthy control group.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Methods</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">: The study design is a double-blind, randomized, controlled clinical trial. Thirty-five participants were randomly assigned to circadian alignment/misalignment protocols. Subjects completed questionnaires as a baseline data (pre-test) and the end of the Interventions (post-test). The instruments were Multidimensional State Boredom Scale<b> (</b>MSBS), Addiction Potential Scale (APS), Depression, Anxiety and Stress Scale-21 (DASS-21), and Barratt Impulsiveness-11 (BIS-11). We categorized participants based on chronotype as mediate variable within each group (circadian aligned & misaligned condition) to analyze outcomes.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">: The mean age of participants was 21.66 years (range: 18-25 years). One-way analysis of variance to compare research variables in groups based on chronotype (evening, intermediate type, and morning types) showed a meaningful difference between the total and non-planning impulsivity, active and passive addiction potential, between the three groups of chronotype (p<0.001).</span></span><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> The results of Bonferny post hoc test to compare the mean of variables in the </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">chronotype</span></span><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> groups about total and non-planning impulsivity scores, active and passive addiction showed that non-planning (p<0.01) and active addiction (p<0.001) in persons with evening and intermediate types were significantly lower than persons with morning type (p=0.02).</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span><br>
<b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Conclusions</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">: Alterations in diurnal profiles of activity, sleep and feeding time, based on chronotype related to impulsiveness and boredom, and such circadian misalignment were associated with addiction potential.</span></span></span></div>
Anxiety, Circadian rhythm, Depression, Stress disorders, Substance-related disorders, Chronobiology, Boredom
0
0
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1425-6&slc_lang=en&sid=1
Mohammad
Niroumand Sarvandani
m.niroumand@live.com
13700319475328460041648
13700319475328460041648
No
Ph.D. Candidate Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
Behzad
Garmabi
behzad.garmabi@gmail.com
13700319475328460041649
13700319475328460041649
No
Assistance Professor School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran, Shahroud, Iran.
Masoud
Asadi
m-asadi@arak.ac.ir
13700319475328460041650
13700319475328460041650
No
Assistance Professor Department of Psychology, Faculty of Humanities, Arak University, Arak, Iran.
Hamed
Ghazvini
hghazvini1@gmail.com
13700319475328460041651
13700319475328460041651
No
Assistance Professor Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Raheleh
Rafaiee
rahelerafaie@gmail.com
13700319475328460041652
13700319475328460041652
No
Assistance Professor Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Hamid
Kalalian Moghaddam
h.kalalian@shmu.ac.ir
13700319475328460041653
13700319475328460041653
Yes
Associate Professor Department of Addiction Studies, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.