Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1402
10
1
gregorian
2024
1
1
15
1
online
1
fulltext
en
The Effect of Omega-3 Supplementation on Serum Levels of Antioxidant Status in Patients With Bipolar Disease: A Randomized Double-blind Controlled Clinical Trial
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction</strong>: Antioxidants prevent the progression of neuropsychiatric disorders, such as bipolar disorder (BD). Omega-3 fatty acid supplementation helps prevent lipid peroxidation and improve antioxidant status. This study aims to investigate the effect of omega-3 supplementation on serum levels of antioxidant status in patients with BD. <br>
<strong>Methods</strong>: In this study, 28 patients with BD received an omega-3 fatty acid supplement (2 g/daily) while the other 28 patients received edible paraffin oil (2 g/daily) for 60 days. The activities of superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (TAC) were evaluated in pre-intervention and post-intervention. <br>
<strong>Results</strong>: The results showed that omega-3 supplementation increased the activities of SOD (12.94±3.84 U/mL vs 17.72±3.59 U/mL) and CAT (5.08±1.61 nmol/min/mL vs 6.43±1.33 nmol/min/mL) in post-intervention compared to pre-intervention (P=0.001). The results also showed that omega-3 supplementation increased the activities of SOD (17.72±3.59 U/mL vs 13.79±3.12 U/mL) and CAT (6.43±1.33 nmol/min/mL vs 4.89±1.45 nmol/min/mL) compared to the control group in post-intervention (P=0.001). Omega-3 supplementation did not have significant effects on the serum concentration of TAC compared to pre-intervention (P=0.373) and control group (P=0.604). <br>
<strong>Conclusion</strong>: Omega-3 supplementation increased the activities of SOD and CAT and may decrease the progression of disease via increasing antioxidant status.</div>
Antioxidant capacity, Bipolar disease, Catalase, Omega-3
109
116
http://bcn.iums.ac.ir/browse.php?a_code=A-10-4292-1&slc_lang=en&sid=1
Dina
Gholipour
dinagholipour@yahoo.com
13700319475328460047859
13700319475328460047859
No
Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran.
Mansour
Shahraki
shahrakimansour@yahoo.com
13700319475328460047860
13700319475328460047860
No
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Mohsen
Saravani
moh.saravani@gmail.com
13700319475328460047861
13700319475328460047861
No
Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.
Abolfazl
Payandeh
payandeh61@gmail.com
13700319475328460047862
13700319475328460047862
No
Community Nursing Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Hadi
Eslahi
hadi_eslahi2015@yahoo.com
13700319475328460047863
13700319475328460047863
Yes
Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran.