Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1396
12
1
gregorian
2018
3
1
0
Accepted Articles
online
1
fulltext
en
The PCSK9 Protein is not necessarily a Risk Factor for MDD
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<div style="text-align: justify;"><span style="font-size:10pt"><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="X-NONE" style="font-size:12.0pt"><span style="line-height:150%">Major depressive disorder (MDD)</span></span><span style="font-size:12.0pt"><span style="line-height:150%"> is </span></span><span lang="X-NONE" style="font-size:12.0pt"><span style="line-height:150%">ne of the common psychiatric disorders</span></span> <span style="font-size:12.0pt"><span style="line-height:150%">that </span></span><span style="font-size:12.0pt"><span style="line-height:150%">is characterized by abnormal neurobiological responses. Proprotein convertase subtilisin/kexin 9 (PCSK9) have a important role in cholesterol homeostasis. This study was aimed to investigate PCSK9 level and oxidative stress with MDD disease</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:150%">.</span></span><span lang="X-NONE" style="font-size:12.0pt"><span style="line-height:150%">The study included 30 with MDD and 30 healthy controls. The. Blood was collected in sterile tubes and the serum PCSK9</span></span> <span lang="X-NONE" style="font-size:12.0pt"><span style="line-height:150%">concentration, SOD and GPx activity were determined by ELISA kits. TAC, TOS, MDA and copper concentration were determined manually.</span></span><span style="font-size:12.0pt"><span style="line-height:150%">There was</span></span><span lang="X-NONE" style="font-size:12.0pt"><span style="line-height:150%"> a significant increase in PCSK9 level in the patient group (<i>p</i><0.05). ROC curve </span></span><span style="font-size:12.0pt"><span style="line-height:150%">had</span></span><span lang="X-NONE" style="font-size:12.0pt"><span style="line-height:150%"> sensitivity of 57% and specificity of 52% </span></span><span style="font-size:12.0pt"><span style="line-height:150%">and </span></span><span lang="X-NONE" style="font-size:12.0pt"><span style="line-height:150%">0.928 (95% CI, 0.86-0.996)</span></span> <span lang="X-NONE" style="font-size:12.0pt"><span style="line-height:150%">for PCSK9, in the patient group (<i>p</i> <0.001). It was found that MDA (<i>p</i> = 0.036) level </span></span><span style="font-size:12.0pt"><span style="line-height:150%">was</span></span><span lang="X-NONE" style="font-size:12.0pt"><span style="line-height:150%"> higher in MDD group, but TAC (<i>p</i> = 0.445) level, SOD (<i>p</i> = 0.148), GPx (<i>p</i> = 0.019) activities and copper concentration were lower in the patient group in compare with the control group.In conclusion, this study results confirm the relationship </span></span><span style="font-size:12.0pt"><span style="line-height:150%">of</span></span><span lang="X-NONE" style="font-size:12.0pt"><span style="line-height:150%"> oxidative stress and major depressive disorder and also suggest a link between PCSK9 and MDD disease.</span></span><span style="font-size:12.0pt"><span style="line-height:150%"></span></span></span></span></span></span></div>
Oxidative stress, Copper, Major depressive disorder and PCSK9
0
0
http://bcn.iums.ac.ir/browse.php?a_code=A-10-4044-1&slc_lang=en&sid=1
Elahe
Habibitabar
elahe.habibi9@gmail.com
13700319475328460041673
13700319475328460041673
No
Medicine Student, Medicine school, Hamadan University of Medical Sciences, Hamadan, Iran.
Shima
Khanverdiloo
sheemaa.kh.92@gmail.com
13700319475328460041674
13700319475328460041674
No
Medicine Student, Medicine school, Hamadan University of Medical Sciences, Hamadan, Iran.
Mona
Doostizadeh
mo.doostizadeh@gmail.com
13700319475328460041675
13700319475328460041675
No
Medicine Student, Medicine school, Hamadan University of Medical Sciences, Hamadan, Iran.
Leila
Jahangard
Jahangard_li_ps@yahoo.com
13700319475328460041676
13700319475328460041676
No
Medicine Student, Medicine school, Hamadan University of Medical Sciences, Hamadan, Iran.
Jamshid
Karimi
jmshdkarimi@yahoo.com
13700319475328460041677
13700319475328460041677
No
Medicine Student, Medicine school, Hamadan University of Medical Sciences, Hamadan, Iran.
gholamreza
shafiee
g.r_shafiee@yahoo.com
13700319475328460041678
13700319475328460041678
Yes
Medicine Student, Medicine school, Hamadan University of Medical Sciences, Hamadan, Iran.