Basic and Clinical Neuroscience Journal

en ‌‌The effect of nicotine administration on physical and psychological signs of withdrawal syndrome induced by single or frequent doses of morphine in rats Cellular and molecular Neuroscience Cellular and molecular Neuroscience Original Original Introduction: Morphine addiction and morphine withdrawal syndrome are the two main problems of today’s human society. The present study has investigated the effects of nicotine on the strength of physical and psychological dependency in single and repeated doses morphine administrated rats. Methods: Male Wistar rats were subjected to morphine consumption with single or frequent dose protocols. In the single dose protocol, rats received only one dose of morphine and 24hrs later they also received one dose of nicotine 30 min prior to injection of naloxone. In the repeated dose protocol, rats received incremental doses of morphine for 7 days and 24hr after the last dose (the 8th day) were given naloxone. However, the nicotine regimen of this group was injected 15 min before the morphine injection, for 4 days, from the 4th to the 7th day. Five minutes after naloxone injection, each rat′s behavior was captured for 30 min, and then physical and psychological signs of withdrawal syndrome were recorded. Data were analyzed by ANOVA followed by Tukey tests and p<0.05 was considered as significant difference. Results: Results showed that the injection of frequent and single doses of morphine lead to morphine dependency. In single dose protocol, nicotine consumption attenuated the signs of withdrawal syndrome, especially weight of excrement and total withdrawal score. In frequent dose protocol, in addition to these effects, nicotine induced weight loss and place aversion. Discussion: The inhibitory effects of nicotine on signs of withdrawal syndrome may involve a dopaminergic portion of the central nervous system and is mediated by central nicotinic receptors. There is also a cross-dependence between nicotine and morphine. Morphine, Nicotine, Withdrawal syndrome, Rat 49 57 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-110&slc_lang=en&sid=1 Ali Shamsizadeh 1370031947532846001661 1370031947532846001661 No Abbas Haghparast 1370031947532846001662 1370031947532846001662 No Ahmad Taghavi Rafsanjani 1370031947532846001663 1370031947532846001663 No Sayed Ali Haeri Rohani3 1370031947532846001664 1370031947532846001664 No Ali Roohbakhsh 1370031947532846001665 1370031947532846001665 No Elham Hakimizadeh 1370031947532846001666 1370031947532846001666 No Fatemeh Amin 1370031947532846001667 1370031947532846001667 No Mohammad Allahtavakoli 1370031947532846001668 1370031947532846001668 Yes