Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1402
6
1
gregorian
2023
9
1
14
5
online
1
fulltext
en
Investigating Facilitatory Effects of Lithium on Methamphetamine-induced Spatial Memory Impairments in Rat
Behavioral Neuroscience
Behavioral Neuroscience
Original
Original
<div style="text-align: justify;"><strong>Introduction</strong>: It has long been known that Methamphetamine (MA), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could facilitate cognitive ability in most of brain diseases. In current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in METH-exposed rats are investigated.<br>
<strong>Methods</strong>: The present study 32 Wistar rats were used to examine the effects of lithium on spatial memory by the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema following MA administrations. <br>
<strong>Results</strong>: The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in MA-treated rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and apoptosis in the CA1 neurons in MA -exposed rats. <br>
<strong>Conclusion</strong>: The results show that treatment with lithium can partially ameliorate the MA –induced neurocognitive deficits in rats, which may be related to its protective effect in the hippocampus.</div>
Lithium, Methamphetamine, Spatial learning and memory, Apoptosis, Brain edema
605
614
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2297-1&slc_lang=en&sid=1
Hamed
Ghazvini
hghazvini1@gmail.com
13700319475328460046653
13700319475328460046653
Yes
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Fatemeh
Tirgar
serah086@yahoo.com
13700319475328460046654
13700319475328460046654
No
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehdi
Khodamoradi
mehdi0khodamoradi@gmail.com
13700319475328460046655
13700319475328460046655
No
Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Seyedeh Masoumeh
Seyedhosseini Tamijani
seyedhoseini_sm@yahoo.com
13700319475328460046656
13700319475328460046656
No
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Saba
Niknamfar
saba.niknam45@gmail.com
13700319475328460046657
0009-0007-8364-4889
No
Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Esmaeil
Akbari
behtarinha00@yahoo.com
13700319475328460046658
13700319475328460046658
No
Department of Physiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mohammad
Nekahi
ma.nekahi@gmail.com
13700319475328460046659
13700319475328460046659
No
Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Nabiollah
Tarjani
amir.twoat@yahoo.com
13700319475328460046660
0009-0008-7663-804X
No
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Hossein
Ghalehnoei
hossein.ghalehnoei58@gmail.com
13700319475328460046661
13700319475328460046661
No
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Motahareh
Rouhi Ardeshiri
motaharerohi340@gmail.com
13700319475328460046662
13700319475328460046662
No
Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.