Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1396
12
1
gregorian
2018
3
1
0
Accepted Articles
online
1
fulltext
en
Effect of Anticholinergic Medications on the Risk of Dementia: A Systematic Review and Meta-Analysis Protocol
Clinical Neuroscience
Clinical Neuroscience
Review
Review
<div style="text-align: justify;"><span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Introduction:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> The most kind of dementia is senile dementia or Alzheimer's disease. </span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Meanwhile, </span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">anticholinergic drugs can potentially modify the risk factors. As different studies have achieved different results and the clinical findings of these interventions have not been conclusive, the objective of this research will be to evaluate the effect of anticholinergic drugs on the risk of dementia. </span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Methods:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> This systematic review and meta-analysis with no language limitation between 1988.12.15 and 2021.12.15 will search WoS, EMBASE, and MEDLINE via PubMed, Scopus, ProQuest electronic databases and grey literature. Our search strategy with suitability criteria covers cohort, case-control, nested case-control, RCTs and non-randomized clinical trial studies evaluating the effect of anticholinergic drugs on the risk of dementia. Two authors will independently implement the selection phases, data extraction, and quality assessment. </span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">The reviewers will evaluate the risk of bias using Newcastle-Ottawa,</span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> Cochrane Risk of Bias Tool and (ROBINS-I) </span></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Quality Assessment Scale. We will conduct a meta-analysis with Random Effect Model or Fixed Effect Model according to severity of methodological heterogeneity. The results will be presented via the forest plot for the composition of final studies’ data, to demonstrate the separated and combined frequency and their corresponding 95% CIs and summary tables and narrative summaries. </span></span></span></span></span></span></span></span><br>
<b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> The results of different studies in this field are various, where findings of this study, along with other studies, will help physicians and other health professionals before prescribing these drugs; the elderly, especially those with polypharmacy, should be carefully assessed for the risk of dementia, Alzheimer's or a variety of cognitive disorders</span></span></span></div>
Anticholinergic Drug, Cholinergic Antagonist, Dementia, Alzheimer, Systematic Review, Meta-analysis
0
0
http://bcn.iums.ac.ir/browse.php?a_code=A-10-3823-1&slc_lang=en&sid=1
Elham
Maraghi
e.maraghi@gmail.com
13700319475328460041235
13700319475328460041235
No
Assistant Professor of Biostatistics, Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
Ali Reza
Safarpour
safarpourar@gmail.com
13700319475328460041236
13700319475328460041236
No
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam
Hajmohammadi
hmohamaddim@gmail.com
13700319475328460041237
13700319475328460041237
No
MSc student of Biostatistics, Student Research Committee, Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
Ali Akbar
Oroojan
aliakbar_oroojan@yahoo.com
13700319475328460041238
13700319475328460041238
No
Department of Physiology, Faculty of Medicine, Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran.
Amal
Saki Malehi
amalsaki@gmail.com
13700319475328460041239
13700319475328460041239
No
Assistant Professor of Biostatistics, Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.
Hadis
Ashrafizadeh
Ashrafizadeh.h1993@gmail.com
13700319475328460041240
13700319475328460041240
Yes
Department of Nursing, School of Nursing and Midwifery, Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.