Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1396
12
1
gregorian
2018
3
1
0
Accepted Articles
online
1
fulltext
en
Short-Term Therapeutic Effects of Anti-Gravity Treadmill Training on Brain Functional Activities and Walking Capacity in Children With Cerebral Palsy
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<strong>Introduction</strong>: Cerebral Palsy (CP) is one of the most common causes of motor disability in childhood. Since CP is a corollary to brain damage, persistent treatment should accompany an alteration in brain functional activity in line with clinical improvements.<br>
<strong>Methods</strong><strong><span dir="RTL">:</span></strong> Fourteen children with spastic hemiplegia CP were randomly divided into 2 groups<span dir="RTL">.</span> The study group (8yrs-5mos) underwent 45min AlterG training sessions 3 times/week for 8 weeks, while the control group (8yrs-2mos) received the same amount of occupational therapy (OT). Functional magnetic resonance imaging (fMRI) was conducted to quantify brain activation during the performance of passive tasks including ankle plantarflexion to dorsiflexion and knee flexion to extension over the range of motion. Walking capacity was assessed using the Timed-Up-and-Go, 10-meter, and 6-minute walk tests. All evaluations were performed before and after training and compared between the two groups.<br>
<strong>Results<span dir="RTL">:</span></strong> We were able to detect the signatures of ankle and knee passive movement tasks in the fMRI and characterize them in terms of activated voxels. The pre-post activation changes following the completion of training course showed that the elicited motor cortex activation was greater for the ankle than the knee tasks. For the ankle, primary motor cortex, precentral gyrus and corpus callosum showed significant enhancement in most study participants. The results indicated 16.1% more active voxels in the study than control groups. Similarly, clinical outcome measures improved over twice as much in this group.<br>
<strong>Conclusions: </strong>AlterG training could be a potentially effective therapeutic intervention for improving gait and balance impairments in children with CP.
Cerebral Palsy (CP), functional Magnetic Resonance Imaging (fMRI), Anti-Gravity Treadmill, Gait
0
0
http://bcn.iums.ac.ir/browse.php?a_code=A-10-3683-2&slc_lang=en&sid=1
Meghdad
Ashtiyani
m.ash.80@gmail.com
13700319475328460038798
13700319475328460038798
No
Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Parmida
Moradi Birgani
parmida.mb@gmail.com
13700319475328460038799
13700319475328460038799
No
Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Maryam
Soleimani
soleimanii.maryam@gmail.com
13700319475328460038800
13700319475328460038800
No
Department of Basic Science, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Seyed Behnamedin
Jameie
behjame@gmail.com
13700319475328460038801
13700319475328460038801
No
Neuroscience Research Centre (NRC), Iran University of Medical Sciences, Tehran, Iran.
Amin
Shahrokhi
amin1350@yahoo.com
13700319475328460038802
13700319475328460038802
No
Department of Basic Science, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Mohammad Reze
Deevband
mdevband@sbmu.ac.ir
13700319475328460038803
13700319475328460038803
Yes
Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Mehdi
Mirbagheri
mehdi.northwestern@gmail.com
13700319475328460038804
13700319475328460038804
No
Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.