en Computational Neuroscience Computational Neuroscience Original Original <div style="text-align: justify;"><strong>Introduction</strong>: Although several studies have been published about COVID-19, ischemic stroke is known yet as a complicated problem for COVID-19 patients. Scientific reports have indicated that in many cases, the incidence of stroke in patients with COVID-19 leads to death.&nbsp;<br> Objectives: The obtained mathematical equation in this study can help physicians&rsquo; decision-making about treatment and identification of influential clinical factors for early diagnosis.&nbsp;<br> <strong>Methods</strong>: In this retrospective study, data from 128 patients between March and September 2020, including their demographic information, clinical characteristics, and laboratory parameters were collected and analyzed statistically. A logistic regression model was developed to identify the significant variables in predicting stroke incidence in patients with COVID-19.&nbsp;<br> <strong>Results</strong>: Clinical characteristics and laboratory parameters for 128 patients (including 76 males and 52 females; with a mean age of 57.109&plusmn;15.97 years) were considered as the inputs that included ventilator dependence, comorbidities, and laboratory tests, including WBC, neutrophil, lymphocyte, platelet count, C-reactive protein, blood urea nitrogen, alanine transaminase (ALT), aspartate transaminase (AST) and lactate dehydrogenase (LDH). Receiver operating characteristic&ndash;area under the curve (ROC-AUC), accuracy, sensitivity, and specificity were considered indices to determine the model capability. The accuracy of the model classification was also addressed by 93.8%. The area under the curve was 97.5% with a 95% CI.<br> <strong>Conclusion</strong>: The findings showed that ventilator dependence, cardiac ejection fraction, and LDH are associated with the occurrence of stroke and the proposed model can predict the stroke effectively.</div> Logistic regression, Stroke, COVID-19, Prediction, SARS-CoV-2 89 100 http://bcn.iums.ac.ir/browse.php?a_code=A-10-3608-1&slc_lang=en&sid=1 Mahsa Babaee mahsa85babaee@gmail.com 13700319475328460047844 13700319475328460047844 No Faculty of Industrial Engineering, Malek Ashtar University of Technology, Tehran, Iran. Karim Atashgar atashgar@alumni.iust.ac.ir 13700319475328460047845 13700319475328460047845 Yes Faculty of Industrial Engineering, Malek Ashtar University of Technology, Tehran, Iran. Ali Amini Harandi ali.amini@sbmu.ac.ir 13700319475328460047846 13700319475328460047846 No Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Atefeh Yousefi 13700319475328460047847 13700319475328460047847 No Department of Neurology, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.