Basic and Clinical Neuroscience Journal

en Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior Clinical Neuroscience Clinical Neuroscience Original Original <div style="text-align: justify;">Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS.</div> Wolfram syndrome, Suicidal behavior, Gene, Mutation, WFS1 gene 893 900 http://bcn.iums.ac.ir/browse.php?a_code=A-10-910-3&slc_lang=en&sid=1 Fatemeh Sadat Mirfazeli mirfazeli.f@iums.ac.ir 13700319475328460043511 13700319475328460043511 No Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran. Fatemeh Mohebi fh.mohebbi@yahoo.com 13700319475328460043512 13700319475328460043512 No Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Amin Jahanbakhshi jahanbakhshi.a@iums.ac.ir 13700319475328460043513 13700319475328460043513 No Skull Base Research Center, Department of Neurosurgery, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. Omid Aryani o_aryani@yahoo.com 13700319475328460043514 13700319475328460043514 No Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Mostafa Almasi-Dooghaee almasidoghaei.m@iums.ac.ir 13700319475328460043515 13700319475328460043515 Yes Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.