en Clinical Neuroscience Clinical Neuroscience Commentary Commentary <div style="text-align: justify;"><strong>Introduction</strong>: High frequency of adverse drug reactions (ADRs) challenges multiple sclerosis (MS) treatment. This study aims to assess the nature and frequency of ADRs induced by MS medications in an observational cross-sectional study.&nbsp;<br> <strong>Methods</strong>: ADRs of all outpatients who had seen a neurologist and had received at least one disease-modifying therapy (DMT) for MS during the last three months were investigated.<br> <strong>Results</strong>: A total of 484 ADRs were detected in these patients. The preventability rate was 5.9%, and 0.61% of reactions were serious.<br> <strong>Conclusion</strong>: The high frequency of adverse drug reactions in this study shows a strong need for strategy planning to increase patients&rsquo; adherence to treatment.</div> Adverse drug reactions, Interferons, Neuropharmacology, Neurology, Compliance 879 884 http://bcn.iums.ac.ir/browse.php?a_code=A-10-2848-2&slc_lang=en&sid=1 Maryam Salehbayat maryyam_101@yahoo.com 13700319475328460047587 13700319475328460047587 No School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran. Roya Abolfazli abolfazl@sina.tums.ac.ir 13700319475328460047588 13700319475328460047588 No Department of Neurology, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Niayesh Mohebbi niayesh_mohebbi@yahoo.com 13700319475328460047589 13700319475328460047589 Yes Department of Clinical Pharmacy, Rational Use of Drugs Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Seyed Mehrdad Savar mehrdad.savar@gmail.com 13700319475328460047590 13700319475328460047590 No Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran. Gloria Shalviri shalviri_g@yahoo.com 13700319475328460047591 13700319475328460047591 No Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran. Kheirollah Gholami khgholami@tums.ac.ir 13700319475328460047592 13700319475328460047592 No Department of Clinical Pharmacy, Rational Use of Drugs Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.