Basic and Clinical Neuroscience Journal

en Distribution of Age and Location of Chordoma in 39 Cases and Review of Treatment Options Clinical Neuroscience Clinical Neuroscience Original Original Introduction: notochord. Although histologically benign, these tumors are locally aggressiveand present significant managment challenges . There arew some studies onevaluated the location, age and gender of the patients with Chordoma in tworeferral centers in Tehran.chordoma cases but there was no study about Iranian cases. In this study weSkull base chordomas are rare neoplasms arising from theMethods: (Shariati and Imam Hospitals, Tehran) from 2001 to 2011 was retrospectivelyreviewed.A database of patients with chordoma tumors referred to two centersResults: women, and they are most commonly diagnosed in middle-aged (mean age was50.6). Tumors typically occur in the axial skeleton and have a tendency for thespheno-occipital region of the skull base and sacral region. In adults 33.3% ofchordomas involve the sacrococcygeal region, 53% occured at the base of theskull near the spheno-occipital area, and near 14% were found in the vertebralcolumn. The cranial nerves mostly affected were abducens, oculomotor andtrochlear, with some overlaps. All patients were treated with surgery and somecases referred for gamma-knife radiosurgery (GKS).In our subjects tumors affect men nearly twice as frequently asDiscussion: to females that is different from other studies, however, few studies reportedmore male to female ratio. Despite the progress in current surgical techniquesand some encouraging results with the use of targeted therapy, disease controland long-term prognosis of patients are still poor.Findings of this study showed more involvement of males compare Chordoma,Skull Base Tumor,Sacral Tumor. 56 59 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-99&slc_lang=en&sid=1 Shahab Kamali Ardekani 1370031947532846001403 1370031947532846001403 Yes Alireza Khoshnevisan 1370031947532846001404 1370031947532846001404 No Ali Shahbazi 1370031947532846001405 1370031947532846001405 No