Basic and Clinical Neuroscience Journal
مجله علوم اعصاب پایه و بالینی
BCN
Medical Sciences
http://bcn.iums.ac.ir
137
journal137
2008-126X
2228-7442
10.32598/bcn
en
jalali
1390
11
1
gregorian
2012
2
1
3
2
online
1
fulltext
en
Distribution of Age and Location of Chordoma in 39 Cases and Review of Treatment Options
Clinical Neuroscience
Clinical Neuroscience
Original
Original
<p align="left" ><b><font face="TimesNewRomanPS-BoldMT" size="2"><font face="TimesNewRomanPS-BoldMT" size="2"><p align="left">Introduction: </p><p align="left">notochord. Although histologically benign, these tumors are locally aggressive</p><font face="TimesNewRomanPSMT" size="2"><font face="TimesNewRomanPSMT" size="2"><font face="TimesNewRomanPSMT" size="2"><font face="TimesNewRomanPSMT" size="2"><p>and present significant managment challenges . There arew some studies on</p></font></font><p></p><p align="left">evaluated the location, age and gender of the patients with Chordoma in two</p><p align="left">referral centers in Tehran.</p></font></font>chordoma cases but there was no study about Iranian cases. In this study we</font></font><font face="TimesNewRomanPSMT" size="2"><font face="TimesNewRomanPSMT" size="2">Skull base chordomas are rare neoplasms arising from the</font></font><b><font face="TimesNewRomanPS-BoldMT" size="2"><font face="TimesNewRomanPS-BoldMT" size="2"><p align="left">Methods: </p><p align="left">(Shariati and Imam Hospitals, Tehran) from 2001 to 2011 was retrospectively</p><p align="left">reviewed.</p></font></font><font face="TimesNewRomanPSMT" size="2"><font face="TimesNewRomanPSMT" size="2">A database of patients with chordoma tumors referred to two centers</font></font><b><font face="TimesNewRomanPS-BoldMT" size="2"><font face="TimesNewRomanPS-BoldMT" size="2"><p align="left">Results: </p><p align="left">women, and they are most commonly diagnosed in middle-aged (mean age was</p><p align="left">50.6). Tumors typically occur in the axial skeleton and have a tendency for the</p><p align="left">spheno-occipital region of the skull base and sacral region. In adults 33.3% of</p><p align="left">chordomas involve the sacrococcygeal region, 53% occured at the base of the</p><p align="left">skull near the spheno-occipital area, and near 14% were found in the vertebral</p><p align="left">column. The cranial nerves mostly affected were abducens, oculomotor and</p><p align="left">trochlear, with some overlaps. All patients were treated with surgery and some</p><p align="left">cases referred for gamma-knife radiosurgery (GKS).</p></font></font><font face="TimesNewRomanPSMT" size="2"><font face="TimesNewRomanPSMT" size="2">In our subjects tumors affect men nearly twice as frequently as</font></font><b><font face="TimesNewRomanPS-BoldMT" size="2"><font face="TimesNewRomanPS-BoldMT" size="2"><p align="left">Discussion: </p><p align="left">to females that is different from other studies, however, few studies reported</p><p align="left">more male to female ratio. Despite the progress in current surgical techniques</p><p align="left">and some encouraging results with the use of targeted therapy, disease control</p><p>and long-term prognosis of patients are still poor.</p></font></font><font face="TimesNewRomanPSMT" size="2"><font face="TimesNewRomanPSMT" size="2">Findings of this study showed more involvement of males compare</font></font></b></b></b></b>
Chordoma,Skull Base Tumor,Sacral Tumor.
56
59
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-99&slc_lang=en&sid=1
Shahab
Kamali Ardekani
1370031947532846001403
1370031947532846001403
Yes
Alireza
Khoshnevisan
1370031947532846001404
1370031947532846001404
No
Ali
Shahbazi
1370031947532846001405
1370031947532846001405
No