en Cellular and molecular Neuroscience Cellular and molecular Neuroscience Original Original <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><b>Background:&nbsp;</b>Dyslexia is a typical learning disability that does not affect intelligence but causes problems with reading, writing, and spelling. It is influenced by<span style="background:white"> certain genes, due to which several researchers have attempted to identify the susceptible gene. Dyslexia is incurable and diagnosis is difficult because it always overlaps with other learning disabilities. Hence, timely assessment and intervention consequently give the best results. Therefore, our aim was to </span>find the relation between dyslexia and single nucleotide polymorphisms (SNPs) in several candidate genes like DYX1C1, KIAA0319, and DCDC2 in Indian population.<span style="background:white"></span><br> <b>Methods:&nbsp;</b><span lang="EN-IN">In the present study, 103 individuals with dyslexia and 100 controls in the age group between 6 to 15 years were taken. Thirteen SNPs in the <i>KIAA </i>gene, seven SNPs of DCDC2, and three SNPs of the DYX1C1 gene were analysed by the Mass Array technique.</span><br> <b>Results:&nbsp;</b><span lang="EN-IN">The association of dyslexia with SNPs <i>rs</i>3756821, <i>rs</i>6935076, <i>rs</i>4576240 of the KIAA gene was found significant.</span> A significant association was found with rs600753 of the DYX1C1 gene and dyslexia and we could not find any association of the DCDC2 gene with dyslexia.<br> <b>Conclusions:&nbsp;</b><span lang="EN-IN">Prerequisite genetic analysis is necessary for the diagnosis of dyslexia as it is a crucial educational barrier. </span><span style="background:white">Treatment is known to be most effective if dyslexia is identified in the early stages for effective intervention for children before they experience prolonged reading failure. Further, it helps in prenatal diagnosis for early intervention.</span></span></span></span></div> Dyslexia, DCDC2, DYX1C1, KIAA gene, SNP 0 0 http://bcn.iums.ac.ir/browse.php?a_code=A-10-3258-1&slc_lang=en&sid=1 Shilpa Reddy Ganasyam shilpareddydr@gmail.com 13700319475328460046572 13700319475328460046572 No Medical Consultant, Clinical Genetics, Institute of Genetics and Hospital for Genetic Diseases, Telangana, India. Manaswini Namilakonda drkmanaswini@gmail.com 13700319475328460046573 13700319475328460046573 Yes Department of Biochemistry, ESIC Medical College and Hospital, Sanathnagar, Telangana, India. Sujatha Madireddy drgenesu@yahoo.co.in 13700319475328460046574 13700319475328460046574 No Medical Consultant, Clinical Genetics, Institute of Genetics and Hospital for Genetic Diseases, Telangana, India. Venkateshwari Ananthapur venkateshwari@yahoo.com 13700319475328460046575 13700319475328460046575 No Institute of Genetics and Hospital for Genetic Diseases, Telangana, India. Srinadh Buragadda aifmrg@hotmail.com 13700319475328460046576 13700319475328460046576 No Medical Consultant, Clinical Genetics, Institute of Genetics and Hospital for Genetic Diseases, Telangana, India. Sunitha Tella tellasunitha@yahoo.in 13700319475328460046577 13700319475328460046577 No Medical Consultant, Clinical Genetics, Institute of Genetics and Hospital for Genetic Diseases, Telangana, India.