en Clinical Neuroscience Clinical Neuroscience Original Original <p align="left" ><p><font color="#221e1f" size="2"><font color="#221e1f" size="2">A two-variable integrate and fire model is presented to study the role of transient </font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">outward potassium currents in producing temporal aspects of dorsal cochlear </font></font></font><font color="#221e1f" size="2"><font color="#221e1f" size="2">nucleus (DCN) pyramidal cells with different profiles namely the chopper, the </font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">pauser and the buildup. This conductance based model is a reduced version of </font></font></font><font color="#221e1f" size="2"><font color="#221e1f" size="2">KM-LIF model (Meng & Rinzel, 2010) which captures qualitative firing features of a detailed physiological model (Kanold & Manis, 2000). For our development we benefit from transient potassium currents properties i.e. fast activation and slow inactivation to generate long latency before start of firing. We compare our minimal model outputs in response to a hyperpolarizing stimulus fallowed by a depolarizing one with the data of KM-LIF model. The results conform well to the KM-LIF model with lower complexity. </font></font></p> Neural Modeling,Transient Potassium Current,Neural Firing,Latency,Dorsal Cochlear Nucleus(DCN). 22 31 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-96&slc_lang=en&sid=1 Zahra Daneshparvar 1370031947532846001412 1370031947532846001412 Yes Mohammad Reza Daliri 1370031947532846001413 1370031947532846001413 No