en Clinical Neuroscience Clinical Neuroscience Original Original <p align="left" ><p><b><font color="#221e1f" size="2"><font color="#221e1f" size="2">Introduction: </font></font></b></p><p><b><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">Stroke is the third important reason of death in adults and an important cause of adult disability. Previous studies suggest that TGF-alpha can induce neurogenesis after stroke. Here in, we studied neurogenesis effects of the TGF-alpha on subventricular zone following ischemia-reperfusion. </font></font></font><b><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"></font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">Male wistar rats (250-300 g) were divided into ischemia and treatment groups. After induction of ischemia-reperfusions, PBS (phosphate buffer salin) </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">and TGF-alpha 50 ng were injected stereotaxicaly in lateral ventricle in ischemia </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">and treatment respectively. After 12 days, the nestin expression in subventricular </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">zone was assessed by immunohistochemical staining method. </font></font></font><b><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><p align="justify"><font size="3">Results:</font> </p></font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">Our results showed that nestin expression increased significantly in treatment group in comparison with ischemia group (p<0.05) . </font></font></font><b><font color="#221e1f" size="2"><font color="#221e1f" size="2"><p><font size="3">Discussion:</font> </p></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">Expression of nestin in SVZ indicates that TGF- α can stimulate the </font></font></font><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2"><font color="#221e1f" face="Times New Roman,Times New Roman" size="2">neural stem cells proliferation after ischemia –reperfusion injury. </font></font></font></b></b></b></b><p></p></p><p align="justify"><font size="3">Methods:</font> </p> Hippocampus,Ischemia,Subventricular Zone,TGF-Alpha 12 15 http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-94&slc_lang=en&sid=1 Hassan Alipanahzadeh 1370031947532846001419 1370031947532846001419 Yes Mansooreh Soleimani 1370031947532846001420 1370031947532846001420 No Sara Soleimani Asl 1370031947532846001421 1370031947532846001421 No Mehdi Mehdizadeh 1370031947532846001422 1370031947532846001422 No